DR. LUCA GILIBERTO, MD, PHD
Neurology in Great Neck, NY
License number
New York 276460
Category
Neurology
Type
Neurology
Address
Address
2
611 Northern Blvd Ste 150 Shore-Lij-Cushing NORTH, Great Neck, NY 11021
300 Community Dr Shore-Lij-Cushing NORTH, North Hills, NY 11030
300 Community Dr Shore-Lij-Cushing NORTH, North Hills, NY 11030
Phone
(516) 325-7000
(516) 325-7001 (Fax)
(516) 562-3029
(516) 562-3631 (Fax)
(516) 325-7001 (Fax)
(516) 562-3029
(516) 562-3631 (Fax)
Professional information
Dr. Luca Giliberto, Manhasset NY - MD (Doctor of Medicine)
Specialties:
Neurology
Address:
300 Community Dr, Manhasset 11030
(516) 562-2303 (Phone), (516) 365-8128 (Fax)
(516) 562-2303 (Phone), (516) 365-8128 (Fax)
Languages:
English
Transgenic Mamals Modifield In Bri Protein Expression
US Patent:
2011005, Mar 3, 2011
Filed:
Nov 20, 2007
Appl. No.:
12/312735
Inventors:
Luciano D'Adamio - Bronx NY, US
Luca Giliberto - Great Neck NY, US
Luca Giliberto - Great Neck NY, US
International Classification:
A01K 67/00, C12N 5/0735, G01N 33/00, C12Q 1/02
US Classification:
800 3, 800 12, 800 14, 435325, 435 29, 800 21
Abstract:
Provided are non-human mammals comprising a transgenic nucleic acid sequence capable of causing an alteration of expression of Bri2 or Bri3 in the mammal. Also provided are non-human mammals comprising a Bri2 or Bri3 gene under the control of the native Bri2 or Bri3 promoter. Additionally provided are non-human mammals genetically engineered to lack expression of a Bri2 or Bri3 gene. Further, non-human mammals comprising a transgene encoding a Bri2 or Bri3 protein under the control of the αCaMKII promoter are provided. Non-human mammals comprising a transgene encoding a furin protein are additionally provided. Embryonic stem cells of any of the above-described non-human mammals are further provided. Methods of screening a compound for treatment of a disease characterized by cerebral amyloidosis are additionally provided. Also provided are methods of making transgenic non-human mammals. Nucleic acids capable of causing an alteration of expression of Bri2 or BH3 if transfected into a mouse are additionally provided, as are comprising a sequence capable of causing an alteration of expression of Bri2 or Bri3 if transfected into a mouse.
Transgenic Mammalls Modified In Bri Protein Expression
US Patent:
2013013, May 23, 2013
Filed:
May 22, 2012
Appl. No.:
13/477397
Inventors:
Luciano D'Adamio - Bronx NY, US
Luca Giliberto - Great Neck NY, US
Luca Giliberto - Great Neck NY, US
International Classification:
A01K 67/027
US Classification:
800 12
Abstract:
Provided are non-human mammals comprising a knock-in nucleic acid sequence capable of causing an alteration of expression of wild-type Bri2 in the mammal or a knockout of wild-type Bri2. Also provided are the non-human mammals as a model for Alzheimer's disease.