Inventors:
Lourens Jan Dirk Zaneveld - Chicago IL
Robert Anthony Anderson - Chicago IL
Xiao Hui Diao - Chicago IL
Paul Robert Young - Oak Park IL
Donald Paul Waller - Oakbrook IL
Sanjay Garg - Chicago IL
Calvin J. Chany - Bolingbrook IL
Assignee:
Rush-Presbyterian, St. Luke's Medical Center - Chicago IL
International Classification:
A61K 4304
Abstract:
A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H. sub. 2 SO. sub. 4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e. g. , nonoxynol-9).