Inventors:
Min Park - Whippany NJ, US
Prasun Chakravarty - Edison NJ, US
Bishan Zhou - Hoboken NJ, US
Edward Gonzalez - Iselin NJ, US
Hyun Ok - Colonia NJ, US
Brenda Palucki - Hillsborough NJ, US
William Parsons - Belle Mead NJ, US
Rosemary Sisco - Old Bridge NJ, US
Michael Fisher - Ringoes NJ, US
Louis Zuegner - Flemington NJ, US
International Classification:
A61K 31/4196, C07D 403/02
Abstract:
Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.