LOUIS JOHN DIETZ
Pilots at High School Way, Mountain View, CA

6603537, Aug 5, 2003

Aug 20, 1999

09/378259

Louis J. Dietz - Mountain View CA
Ian Walton - Redwood City CA
Scott Norton - Sunnyvale CA

SurroMed, Inc. - Mountain View CA

G01J 330

356 39, 356317, 356417, 2504581

Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).

6687395, Feb 3, 2004

Apr 26, 2000

09/558094

Louis J. Dietz - Mountain View CA
Ian Walton - Redwood City CA
Chih-Hua Chung - Fremont CA
Scott Norton - Sunnyvale CA
James L. Winkler - Sunnyvale CA
Aaron B. Kantor - Newark CA
Byron Lee - San Jose CA
Shalom Tsur - Mountain View CA

SurroMed, Inc. - Mountain View CA

G06K 900

382133, 359201

The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

6780301, Aug 24, 2004

Oct 2, 2000

09/677203

Michael J. Natan - Los Altos CA
Thomas E. Mallouk - State College PA
Benjamin R. Martin - State College PA
Brian D. Reiss - State College PA
Louis J. Dietz - Mountain View CA
James L. Winkler - Sunnyvale CA

Surromed, Inc. - Menlo Park CA

C25D 502

205118, 205122

Synthetic methods for the manufacture of segmented nanoparticles are described.

6800860, Oct 5, 2004

Aug 5, 2003

10/635917

Louis J. Dietz - Mountain View CA
Ian Walton - Mountain View CA
Scott Norton - Sunnyvale CA

SurroMed, Inc. - Menlo Park CA

G01N 2164

2504581, 2504591, 356317, 356318

Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).

5689110, Nov 18, 1997

Jun 27, 1996

8/670540

Louis J. Dietz - Mountain View CA
Thomas M. Baer - Mountain View CA

Biometric Imaging, Inc. - Mountain View CA

G01J 3443

2502521A

A calibration method and device for a fluorescence spectrometer which uses fluorescence from a homogeneous solid state standard as the source of calibration fluorescence and wherein the solid state standard may be built into the optical scanner and the calibration may be automatically performed as a routine step when using the optical scanner. A gold standard establishes fluorescent units, and the fluorescence spectrometer is calibrated by reference to calibration standards, such as calibration rubies, which are themselves rated against the gold standard and built into the fluorescence spectrometer to provide an unchanging reference to the gold standard and by which simultaneous calibration of two or more channels of a multi-channel fluorescence spectrometer may be accomplished, including automatically calibrating a multi-channel optical scanner when it is turned on to achieve an acceptable level of sensitivity in each channel and to adjust for any relative shift in sensitivity between the channels.

2003007, Apr 24, 2003

Oct 18, 2002

10/274297

Steven Potts - San Diego CA, US
Louis Dietz - Mountain View CA, US
Aaron Kantor - San Carlos CA, US
Brenton Reynolds - Palo Alto CA, US
Ian Walton - Redwood City CA, US

SURROMED, INC. - Mountain View CA

G05D001/00

701/001000

A database-driven cytometry network allows for acquisition, analysis, and viewing of large amounts of cytometry data from multiple cytometers. Data from multiple instruments are uploaded to a database, where combined compensation and calibration matrices are applied automatically to correct for both spectral overlap among acquisition channels and instrument-dependent variations. The resulting instrument-independent data are gated automatically using common template gates. A user at a client computer can view and perform statistical analyses on any desired subset of the gated data.

7336812, Feb 26, 2008

Feb 3, 2004

10/771585

Louis J Dietz - Mountain View CA, US
Ian Walton - Redwood City CA, US
Chih-Hua Chung - Fremont CA, US
Scott Norton - Sunnyvale CA, US
James L Winkler - San Diego CA, US
Aaron B Kantor - San Carlos CA, US
Byron Lee - San Jose CA, US
Shalom Tsur - Mountain View CA, US

PPD Biomarker Discovery Sciences, LLC - Wilmington NC

G06K 9/00, G06K 9/46, G06K 99/66, G06K 9/38

382134, 382165, 382191, 382192, 382270

The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

5547849, Aug 20, 1996

May 2, 1994

8/236342

Thomas M. Baer - Mountain View CA
Louis J. Dietz - Mountain View CA
Robert S. Dubrow - San Carlos CA
Paul G. Hayter - Los Altos CA
Michael Hodges - Palo Alto CA
Bala S. Manian - Los Altos Hills CA
Robert J. Shartle - Livermore CA

Biometric Imaging, Inc. - Mountain View CA

G01N 33536

435 724

The apparatus and method of the present invention disclose a scanning imaging cytometer wherein an unprocessed biological fluid sample is reacted with a fluorescently-labeled binding agent. The reacted sample undergoes minimal processing before it is placed into a capillary tube. The sample is optically scanned and fluorescence excitation is recorded from a plurality of columnar regions of the capillary tube, each columnar region generally defined by the spot size of the excitation beam and the depth dimension of the capillary tube. A spatial filter of a sufficient pinhole diameter is selected to allow simultaneous volumetric detection of all fluorescent targets in each columnar region.

7259845, Aug 21, 2007

Jul 19, 2005

11/185430

Louis J. Dietz - Mountain View CA, US
Christopher E. Todd - San Jose CA, US

PPD Biomarker Discovery Sciences LLC - Wilmington NC

G01N 1/10

356246

A disposable cuvette cartridge for optical measurements is formed from three flexible thin layers. The middle layer is an adhesive sheet with cut out regions, typically between 30 and 50, serving as optical chambers bounded by the two outer layers. Inlet and vent holes in one of the outer sheets provide access to the optical chambers. At least one of the outer sheets is made of a material having low fluorescence, such as a cyclo-olefin copolymer. With its low background fluorescence, the cuvette cartridge is useful for high-throughput fluorescence measurements of biological samples.

2003020, Nov 13, 2003

Apr 11, 2003

10/410834

Michael Natan - Los Altos CA, US
Thomas Mallouk - State College PA, US
Benjamin Martin - State College PA, US
Brian Reiss - State College PA, US
Louis Dietz - Mountain View CA, US
James Winkler - Sunnyvale CA, US

NANOPLEX, TECHNOLOGIES

C25D017/00

204/273000

Segmented nanoparticles are manufactured according to different methods and in various apparatuses.