Inventors:
DEEPAK Ramesh THAKKER - BLAINE MN, US
CARL A. SHU - PLYMOUTH MN, US
ERIC NEAL BURRIGHT - EAGAN MN, US
PAUL W. WACNIK - MINNEAPOLIS MN, US
JENNIFER M. HEISEL - PRINCETON MN, US
LOTHAR KRINKE - EDEN PRAIRIE MN, US
Assignee:
MEDTRONIC, INC. - MINNEAPOLIS MN
International Classification:
A61M 37/00, C12N 15/11, A61B 6/00, A61N 1/30, A61N 1/36
US Classification:
600431, 435446, 607 3, 604 21
Abstract:
The instant invention provides a method for improving efficiency of RNA delivery to cells. The method comprises applying a low strength electric field to the cells and then after a certain time period, administering the ribonucleic acid sequence to the cells. Devices, kits, and RNA molecules suitable for delivery and devices suitable for practicing the disclosed methods are also provided.