Inventors:
Jami B. Wollan - Mountlake Terrace WA, US
Lori A. Jones - Seattle WA, US
Assignee:
Dendreon Corporation - Seattle WA
International Classification:
A61K 39/00, G01N 33/53, C12Q 1/02, C12N 5/10, C12N 1/21, C07H 21/04, C12N 15/63, A61K 38/00, A61K 38/10, A61P 37/00, C07K 7/08, A61K 38/19, C12N 1/19
US Classification:
424 851, 4241851, 435 792, 435 29, 435325, 435348, 4352523, 43525231, 43525233, 4352542, 4353201, 514 11, 514 214, 514 215, 530300, 530326, 530327, 536 231, 536 234
Abstract:
The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.