LOREE C HELLER
Medical Practice at Ter Hl Dr, Tampa, FL
License number
Florida 38393
Issued Date
Dec 2, 2003
Effective Date
Sep 16, 2010
Expiration Date
Aug 31, 2008
Category
Health Care
Type
Clinical Laboratory Personnel
Address
Address
509 Terrace Hill Dr, Tampa, FL 33617
Phone
(813) 844-4677
Professional information
Electroporation And Electrophoresis System And Method For Achieving Molecular Penetration Into Cells In Vivo
US Patent:
6714816, Mar 30, 2004
Filed:
Feb 22, 2000
Appl. No.:
09/507859
Inventors:
Richard Heller - Temple Terrace FL
Richard Gilbert - Tampa FL
Mark J. Jaroszeski - Tampa FL
Loree C. Heller - Temple Terrace FL
Melinda L. Lucas - Tampa FL
Richard Gilbert - Tampa FL
Mark J. Jaroszeski - Tampa FL
Loree C. Heller - Temple Terrace FL
Melinda L. Lucas - Tampa FL
Assignee:
University of South Florida - Tampa FL
International Classification:
A61N 500
US Classification:
607 3, 604 20
Abstract:
The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
Electroporation And Electrophoresis System And Method For Achieving Molecular Penetration Into Cells In Vivo
US Patent:
7668592, Feb 23, 2010
Filed:
Jul 23, 2007
Appl. No.:
11/781619
Inventors:
Richard Heller - Temple Terrace FL, US
Richard Gilbert - Tampa FL, US
Mark J. Jaroszeski - Tampa FL, US
Loree C. Heller - Temple Terrace FL, US
Melinda L. Lucas - Tampa FL, US
Richard Gilbert - Tampa FL, US
Mark J. Jaroszeski - Tampa FL, US
Loree C. Heller - Temple Terrace FL, US
Melinda L. Lucas - Tampa FL, US
Assignee:
University of South Florida - Tampa FL
International Classification:
A61N 1/30
US Classification:
604 20
Abstract:
The electroporation system and method combine pulses having different characteristics for delivering molecules to cells in vivo. The pulses include a high-intensity pulse for inducing electroporation and a low-intensity pulse to induce electrophoretic molecule movement within an interstitial space, molecule adherence to a cell membrane, and electrophoretic movement of the molecule through the permeabilized membrane. The use of a high-intensity and a low-intensity pulse achieves improved delivery; reduction of intensity and/or duration of pulses for inducing electroporation; and decreased muscle stimulation, tissue damage, and patient discomfort.
Method Of Enhancing Therapeutic Effect Of Nucleic Acids
US Patent:
2006027, Nov 30, 2006
Filed:
Aug 11, 2005
Appl. No.:
11/161665
Inventors:
Loree Heller - Tampa FL, US
Richard Gilbert - Tampa FL, US
Mark Jaroszeski - Tampa FL, US
Richard Heller - Tampa FL, US
Richard Gilbert - Tampa FL, US
Mark Jaroszeski - Tampa FL, US
Richard Heller - Tampa FL, US
Assignee:
UNIVERSITY OF SOUTH FLORIDA - Tampa FL
International Classification:
A61K 48/00, A61N 1/00
US Classification:
514044000, 607002000
Abstract:
The present invention is a method of eliciting an antitumor effect in vivo comprising the steps of identifying a species representative of a treatment subject, identifying at least one non-coding nucleic acid sequence, introducing the at least one nucleic acid to at least one tumor in the treatment subject and applying an energy source to the at least one tumor. The energy source may comprise, but is not limited to, electrical, sonic, photonic, and microwave output.