Inventors:
Francis S. Collins - Ann Arbor MI
Margaret R. Wallace - Ann Arbor MI
Douglas A. Marchuk - Ann Arbor MI
Lone B. Andersen - Ann Arbor MI
David H. Gutmann - Ann Arbor MI
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C12Q 168, C12P 1934, C07H 2104, C07K 14435
Abstract:
The invention relates to the gene involved in the von Recklinghausen neurofibromatosis (NF1) disease process and to the identification, isolation and cloning of a nucleic acid sequence corresponding to the gene. The invention further relates to the NF1 gene product and sequence and antibodies raised thereto. The invention also relates to methods of screening for NF1 and NF1 diagnosis, as well as conventional treatment and gene therapy utilizing recombinant technologies.