Inventors:
Lloyd P. Aiello - Belmont MA, US
Tamie Jo Chilcote - San Francisco CA, US
Sukanto Sinha - San Francisco CA, US
Edward P. Feener - North Reading MA, US
Assignee:
JOSKIN DIABETES CENTER - BOSTON MA
ACTIVESITE PHARMACEUTICALS, INC. - SAN FRANCISCO CA
International Classification:
A61K 31/4439, A61K 31/415, A61K 31/341, A61K 31/4192, A61K 31/381, A61K 31/426, A61K 31/4436, A61P 9/00, A61K 31/404, A61K 31/343, A61P 3/10, A61P 9/12, A61P 31/00, A61P 25/00
US Classification:
514343, 514406, 514461, 514359, 514448, 514365, 514336, 514419, 514469, 514443
Abstract:
We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability) and astrocyte activation. Diseases and conditions associated with increased vascular permeability include diabetic retinopathy, hemorrhagic stroke, and macular edema. Diseases and conditions associated with astrocyte activation include Alzheimer's disease, multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, stroke, epilepsy, and brain trauma.