Inventors:
Jack A. Elias - Woodbridge CT, US
Chirag R. Parikh - Wallingford CT, US
Lloyd G. Cantley - East Haven CT, US
International Classification:
G01N 33/566, A61P 13/12, A61K 38/17, C12Q 1/68, C40B 30/04
US Classification:
514 154, 436501, 435 71, 435 792, 435 611, 435 612, 506 9
Abstract:
The present invention provides compositions and methods for the detection, treatment, and prevention of a kidney injury. The invention relates to the discovery that chitinase 3-like 1/Brp-39/YKL-40 serves as both a biomarker for the degree of kidney injury and a critical mediator of a reparative response in the kidney.