Inventors:
Bo Kowalczyk - Orland Park IL, US
Zhao Li - Naperville IL, US
Ralph Schure - Darien IL, US
Lisa Dunkle - Madison CT, US
Assignee:
Achillion Pharmaceuticals, Inc. - New Haven CT
International Classification:
A61K031/7072, C07H019/00, C07H019/048
US Classification:
514/050000, 536/028200, 536/055300
Abstract:
The invention provides a method of synthesizing -L-5-fluoro-2′,3′-dideoxy-2′,3′-didehydrocytidine (-L-FD4C). The method allows for large-scale production of -L-FD4C in an efficient, cost-effective, and environmentally sound manner.