LING WANG, RN
Nursing at Othello St, Seattle, WA
License number
Washington RN00118084
Category
Nursing
Type
Registered Nurse
Address
Address
3815 S Othello St FL 2, Seattle, WA 98118
Phone
(206) 788-3500
(206) 788-3521 (Fax)
(206) 788-3521 (Fax)
Professional information
Law Practice Professional
Location:
Greater Seattle Area
Industry:
Law Practice
Methods And Compositions For Modulating P300/Cbp Activity
US Patent:
8476458, Jul 2, 2013
Filed:
Jun 19, 2008
Appl. No.:
12/665751
Inventors:
Ronen Marmorstein - Swarthmore PA, US
Xin Liu - Menlo Park CA, US
Philip A. Cole - Baltimore MD, US
Ling Wang - Seattle WA, US
Erin M. Bowers - Baltimore MD, US
David J. Meyers - Towson MD, US
Chandrani Mukherjee - Baltimore MD, US
Xin Liu - Menlo Park CA, US
Philip A. Cole - Baltimore MD, US
Ling Wang - Seattle WA, US
Erin M. Bowers - Baltimore MD, US
David J. Meyers - Towson MD, US
Chandrani Mukherjee - Baltimore MD, US
Assignee:
The Wistar Institute - Philadelphia PA
The John Hopkins University - Baltimore MD
The John Hopkins University - Baltimore MD
International Classification:
C07D 231/00, C07D 231/06, C07D 307/00, C07D 317/00, C07D 323/02
US Classification:
5483657, 5483561, 5483661, 5483791, 549429
Abstract:
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.
Methods And Compositions For Modulating P300/Cbp Activity
US Patent:
2013034, Dec 26, 2013
Filed:
May 30, 2013
Appl. No.:
13/905222
Inventors:
Philip A. Cole - Baltimore MD, US
Ling Wang - Seattle WA, US
Erin M. Bowers - Baltimore MD, US
David J. Meyers - Towson MD, US
Chandrani Mukherjee - Baltimore MD, US
Ling Wang - Seattle WA, US
Erin M. Bowers - Baltimore MD, US
David J. Meyers - Towson MD, US
Chandrani Mukherjee - Baltimore MD, US
International Classification:
C07D 405/06
US Classification:
514369, 435184, 514404, 514375, 435 74, 506 8, 5483657, 506 9, 548183, 548224
Abstract:
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.