Inventors:
Sharon Keeler - Bear DE, US
Sheryl Wolstenholme - Elkton MD, US
Jodie Duke - Newark DE, US
Linda Hnatow - Oxford PA, US
International Classification:
A61K 39/02, A61K 9/70, C07H 21/04, C12P 21/06, C12N 15/74, C07K 14/195, C12N 1/21
US Classification:
424190100, 435069100, 435252300, 435471000, 530350000, 424443000, 536023700
Abstract:
A process was developed for expressing antimicrobial peptides in a recombinant host cell that eliminates host cell toxicity and antimicrobial peptide degradation, as well as providing a process for rapid purification. Fusion proteins comprising a periplasmic targeting signal, cleavage site, and antimicrobial peptides provide the basis for this process which produces antimicrobial peptides that may be used in antimicrobial compositions and articles.