LINDA BENTLEY JOHNSON, M.S, L.L.P.
Social Work at Enterprise Ct, Farmington, MI

License number

Michigan 012750

Professional information

Linda B Johnson, Farmington Hills MI - MS (Mitral stenosis; also Master of Science or Medical scientist)

Specialties:

Psychology, Clinical Psychology, Cognitive & Behavioral Psychology

Address:

37634 Enterprise Ct, Farmington Hills 48331
(248) 553-0902 (Phone)

Languages:

English

Tricyclic Inhibitors Of Matrix Metalloproteinases

US Patent:

5665764, Sep 9, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/460436

Inventors:

Donald Hupe - Ann Arbor MI
Linda Lea Johnson - Ann Arbor MI
Joseph Armand Picard - Canton MI
Andrew David White - Lakeland MI

Assignee:

Warner-Lambert Company - Morris Plains, NJ

International Classification:

A61K 3134

US Classification:

514468

Abstract:

Tricyclic compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, cancer metastasis, tumor angionenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.

Process For The Production Of Gelatinase Catalytic Domain Protein

US Patent:

5646027, Jul 8, 1997

Filed:

Sep 8, 1994

Appl. No.:

8/303270

Inventors:

Linda Lea Johnson - Ann Arbor MI
Donald John Hupe - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C12N 1557, C12N 1563, C12P 2100

US Classification:

435219

Abstract:

A process for the production of the catalytic domain, without propeptide, C-terminal domain, and the fibronectin-like insert, of human gelatinases is described which comprises culturing transformed E. coli host cells carrying a synthetic DNA sequence encoding the catalytic domain as well as a method for screening for inhibitors of a gelatinase; a method for determining the 3-dimensional structure of the catalytic domain of a gelatinase; and pharmaceutical compositions of human gelatinase catalytic domain protein which are useful in treating herniated vertebral discs, dermal ulcers, modifying scar tissue formation, and joint diseases.

Tricyclic Inhibitors Of Matrix Metalloproteinases

US Patent:

5958972, Sep 28, 1999

Filed:

May 20, 1997

Appl. No.:

8/859437

Inventors:

Donald Hupe - Ann Arbor MI
Linda Lea Johnson - Ann Arbor MI
Joseph Armand Picard - Canton MI
Andrew David White - Lakeland MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31215, A61K 3144

US Classification:

514529

Abstract:

Tricyclic compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.

Tricyclic Inhibitor Of Matrix Metalloproteinases

US Patent:

5627206, May 6, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/460437

Inventors:

Donald Hupe - Ann Arbor MI
Linda Lea Johnson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D30791, A61K 3134

US Classification:

514468

Abstract:

A tricyclic compound is described as well as pharmaceutical compositions of same, which is useful as an inhibitor of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) for the treatment of multiple sclerosis or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.

Aromatic Keto-Acids And Their Derivatives As Inhibitors Of Matrix Metalloproteinases

US Patent:

6008220, Dec 28, 1999

Filed:

Jun 8, 1998

Appl. No.:

9/077715

Inventors:

Donald Hupe - Ann Arbor MI
Linda Lea Johnson - Ann Arbor MI
Daniel Fred Ortwine - Saline MI
Claude Forsey Purchase - Ann Arbor MI
Andrew David White - Lakeland MI

Assignee:

Warner Lambert Company - Morris Plains NJ

International Classification:

A61K 31445, A61K 31495, C07D21134, C07D24104

US Classification:

514252

Abstract:

Aromatic keto-acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, arthrities, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.

Process For The Production Of Stromelysin Catalytic Domain Protein

US Patent:

6284513, Sep 4, 2001

Filed:

Jul 27, 1994

Appl. No.:

8/281313

Inventors:

Linda Lea Johnson - Ann Arbor MI
Donald John Hupe - Ann Arbor MI
Vijaykumar Baragi - Ann Arbor MI

Assignee:

Warner-Lambert Company - Ann Arbor MI

International Classification:

A61L 901

US Classification:

435226

Abstract:

A process for the production of the catalytic domain, without propeptide, of a matrix metalloproteinase is described which comprises culturing transformed host cells carrying a DNA sequence encoding the catalytic domain as well as a method for screening for inhibitors of a matrix metalloproteinase; a method for determining the 3-dimensional structure of the catalytic domain of a matrix metalloproteinase; and pharmaceutical compositions of human stromelysin catalytic domain protein which are useful in treating herniated vertebral discs, dermal ulcers, modifying scar tissue formation, and joint diseases.