Inventors:
Ellis Reinherz - Lincoln MA, US
Linda Clayton - Jamaica Plain MA, US
Emma Fiorini - Cambridge MA, US
Pedro Reche - Boston MA, US
Ingo Schmitz - Kaarst, DE
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
G01N033/574, C07H021/04, C12N009/64
US Classification:
435007230, 536023200, 435069100, 435226000, 435320100, 435325000
Abstract:
The identification of a novel gene, termed IκBNS, regulated during negative selection of immature CD4CD8double positive (DP) thymocytes in mice, and the human homolog of the gene, are described, along with the gene products produced by these genes. Methods of using the disclosed genes and gene products are also described.