LIMING NI, PHARM. D., PH. D.
Pharmacy at Rucker Blvd, Enterprise, AL
License number
Alabama 17227
Category
Pharmacy
Type
Pharmacist
License number
Alabama RPH026609
Category
Pharmacy
Type
Pharmacist
Address
Address
2
900 Rucker Blvd, Enterprise, AL 36330
185 Whitestone Ct, Duluth, GA 30097
185 Whitestone Ct, Duluth, GA 30097
Phone
(334) 393-1348
(678) 895-4690
(678) 895-4690
Professional information
2-Thiopyrimidinones As Therapeutic Agents
US Patent:
2006010, May 11, 2006
Filed:
Sep 12, 2005
Appl. No.:
11/224424
Inventors:
James Sikorski - Atlanta GA, US
Jason Skudlarek - Suwanee GA, US
Linda Hamaker - Humble TX, US
Liming Ni - Duluth GA, US
M. Weingarten - Cumming GA, US
Jason Skudlarek - Suwanee GA, US
Linda Hamaker - Humble TX, US
Liming Ni - Duluth GA, US
M. Weingarten - Cumming GA, US
International Classification:
A61K 31/513, C07D 403/02
US Classification:
514269000, 544309000, 544310000
Abstract:
The present invention provides compounds of Formulas I-VII, or pharmaceutically acceptable derivatives thereof, wherein the compounds are as defined in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of MEKK protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders, such as inflammatory disorders.
1, 3-Bis-(Substituted-Phenyl)-2-Propen-1-Ones And Their Use To Treat Vcam-1 Mediated Disorders
US Patent:
6608101, Aug 19, 2003
Filed:
Jun 20, 2001
Appl. No.:
09/886348
Inventors:
Liming Ni - Duluth GA
Lee K. Hoong - Suwanee GA
James A. Sikorski - Alpharetta GA
Charles Q. Meng - Alpharetta GA
Lee K. Hoong - Suwanee GA
James A. Sikorski - Alpharetta GA
Charles Q. Meng - Alpharetta GA
Assignee:
Atherogenics, Inc. - Alpharetta GA
International Classification:
A61K 3138
US Classification:
514443, 514438, 549 58, 549 78
Abstract:
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.
1,3-Bis-(Substituted-Phenyl)-2-Propen-1-Ones And Their Use To Treat Vcam-1 Mediated Disorders
US Patent:
2006025, Nov 16, 2006
Filed:
Jul 13, 2006
Appl. No.:
11/485940
Inventors:
Charles Meng - Alpharetta GA, US
Liming Ni - Duluth GA, US
James Sikorski - Alpharetta GA, US
Lee Hoong - Suwanee GA, US
Liming Ni - Duluth GA, US
James Sikorski - Alpharetta GA, US
Lee Hoong - Suwanee GA, US
International Classification:
A61K 31/381
US Classification:
514443000, 514263100, 514252100, 514311000, 514307000, 514419000, 514396000, 514381000, 514416000, 514394000, 514411000
Abstract:
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.
1,3-Bis-(Substituted-Phenyl)-2-Propen-1-Ones And Their Use To Treat Vcam-1 Mediated Disorders
US Patent:
7078431, Jul 18, 2006
Filed:
May 21, 2003
Appl. No.:
10/443470
Inventors:
Charles Q. Meng - Alpharetta GA, US
Liming Ni - Duluth GA, US
James A. Sikorski - Alpharetta GA, US
Lee K. Hoong - Suwanee GA, US
Liming Ni - Duluth GA, US
James A. Sikorski - Alpharetta GA, US
Lee K. Hoong - Suwanee GA, US
Assignee:
Atherogenics, Inc. - Alpharetta GA
International Classification:
A61K 31/38, A61K 31/36, A61K 31/435, C07D 409/00, C07C 49/213
US Classification:
514438, 514444, 514464, 514342, 514277, 514678, 514679, 549 78, 549 58, 549444, 549 60, 5462804, 546340, 568308, 568325
Abstract:
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are mediated by VCAM-1 include, but are not limited to arthritis, asthma, dermatitis, cystic fibrosis, post transplantation late and chronic solid organ rejection, multiple sclerosis, systemic lupus erythematosis, inflammatory bowel diseases, autoimmune diabetes, diabetic retinopathy, rhinitis, ischemia-reperfusion injury, post-angioplasty restenosis, chronic obstructive pulmonary disease (COPD), glomerulonephritis, Graves disease, gastrointestinal allergies, conjunctivitis, atherosclerosis, coronary artery disease, angina and small artery disease.
Process Of Making Chalcone Derivatives
US Patent:
2004018, Sep 16, 2004
Filed:
Dec 19, 2003
Appl. No.:
10/741283
Inventors:
M. Weingarten - Cummings GA, US
Liming Ni - Duluth GA, US
Charles Meng - Alpharetta GA, US
Kimberly Worsencroft - Alpharetta GA, US
James Sikorski - Atlanta GA, US
Liming Ni - Duluth GA, US
Charles Meng - Alpharetta GA, US
Kimberly Worsencroft - Alpharetta GA, US
James Sikorski - Atlanta GA, US
International Classification:
C07D257/02, C07D207/46
US Classification:
548/253000, 548/577000
Abstract:
This invention is a novel methods of manufacturing chalcones that includes reacting a carbon-linked heteroaryl or heterocyclic substituted benzaldehyde with an acetophenone in a solvent or mixture of solvents in the presence of LiOMe. Also provided are new chalcones for the treatment of medical conditions.
Sulfonamide-Substituted Chalcone Derivatives And Their Use To Treat Diseases
US Patent:
2007009, Apr 26, 2007
Filed:
Dec 15, 2006
Appl. No.:
11/640509
Inventors:
Kimberly Worsencroft - Alpharetta GA, US
Liming Ni - Duluth GA, US
Zhihong Ye - Lilburn GA, US
Charles Meng - Alpharetta GA, US
M. Weingarten - Cumming GA, US
Jacob Simpson - Lawrenceville GA, US
James Sikorski - Atlanta GA, US
Liming Ni - Duluth GA, US
Zhihong Ye - Lilburn GA, US
Charles Meng - Alpharetta GA, US
M. Weingarten - Cumming GA, US
Jacob Simpson - Lawrenceville GA, US
James Sikorski - Atlanta GA, US
Assignee:
AtheroGenics, Inc. - Alpharetta GA
International Classification:
A61K 31/695, A61K 31/5377, A61K 31/42, A61K 31/506, A61K 31/4439, A61K 31/41, A61K 31/381, C07D 413/02, C07D 409/02
US Classification:
514063000, 514275000, 514378000, 514381000, 514342000, 514370000, 514406000, 514337000, 514235200, 514252130, 514419000, 514326000, 544146000, 544379000, 548190000, 548247000, 548253000, 548110000, 548465000, 549076000, 544331000, 546277100
Abstract:
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.
Spiro Compounds For Treatment Of Inflammatory Disorders
US Patent:
2008028, Nov 13, 2008
Filed:
May 9, 2008
Appl. No.:
12/151919
Inventors:
M. David Weingarten - Cumming GA, US
Liming Ni - Duluth GA, US
Zhihong Ye - Lilburn GA, US
Charles Q. Meng - Duluth GA, US
Raymond Ng - Alpharetta GA, US
Jim A. Sikorski - Atlanta GA, US
Liming Ni - Duluth GA, US
Zhihong Ye - Lilburn GA, US
Charles Q. Meng - Duluth GA, US
Raymond Ng - Alpharetta GA, US
Jim A. Sikorski - Atlanta GA, US
International Classification:
A61K 31/352, C07D 493/10, A61P 29/00, A61P 11/00
US Classification:
514453, 549344
Abstract:
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of an inflammatory condition, in particular asthma. The compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof:wherein Y, Z and R-Rare defined herein.
Sulfonamide-Substituted Chalcone Derivatives And Their Use To Treat Diseases
US Patent:
7173129, Feb 6, 2007
Filed:
Jun 7, 2004
Appl. No.:
10/863115
Inventors:
Kimberly J. Worsencroft - Alpharetta GA, US
Liming Ni - Duluth GA, US
Zhihong Ye - Lilburn GA, US
Charles Q. Meng - Alpharetta GA, US
M. David Weingarten - Cumming GA, US
Jacob E. Simpson - Lawrenceville GA, US
James A. Sikorski - Atlanta GA, US
Liming Ni - Duluth GA, US
Zhihong Ye - Lilburn GA, US
Charles Q. Meng - Alpharetta GA, US
M. David Weingarten - Cumming GA, US
Jacob E. Simpson - Lawrenceville GA, US
James A. Sikorski - Atlanta GA, US
Assignee:
Athero Genics, Inc. - Alpharetta GA
International Classification:
C07D 413/00, C07D 419/00, C07D 239/02, C07D 403/00, C07D 405/00, C07D 409/00, C07D 411/00
US Classification:
544137, 544143, 544297, 544372, 544374, 546213, 5462764, 5462804, 5462814, 548194, 548246, 548247, 548253, 5483147, 5483151, 5483657, 548406, 548509, 548510, 548511, 548571
Abstract:
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula.
Chalcone Derivatives And Their Use To Treat Diseases
US Patent:
2006018, Aug 24, 2006
Filed:
Jan 20, 2006
Appl. No.:
11/337207
Inventors:
Liming Ni - Duluth GA, US
Kimberly Worsencroft - Alpharetta GA, US
M. Weingarten - Cummings GA, US
Charles Meng - Alpharetta GA, US
James Sikorski - Atlanta GA, US
Kimberly Worsencroft - Alpharetta GA, US
M. Weingarten - Cummings GA, US
Charles Meng - Alpharetta GA, US
James Sikorski - Atlanta GA, US
International Classification:
A61K 31/70, A61K 31/445, A61K 31/41, A61K 31/40
US Classification:
514025000, 514114000, 514381000, 514317000, 514408000, 514616000, 514464000, 514679000
Abstract:
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.
Chalcone Derivatives And Their Use To Treat Diseases
US Patent:
7094801, Aug 22, 2006
Filed:
Dec 19, 2002
Appl. No.:
10/324987
Inventors:
James A. Sikorski - Atlanta GA, US
Charles Q. Meng - Alpharetta GA, US
M. David Weingarten - Cummings GA, US
Kimberly J. Worsencroft - Alpharetta GA, US
Liming Ni - Duluth GA, US
Charles Q. Meng - Alpharetta GA, US
M. David Weingarten - Cummings GA, US
Kimberly J. Worsencroft - Alpharetta GA, US
Liming Ni - Duluth GA, US
Assignee:
Atherogenics, Inc. - Alpharetta GA
International Classification:
A61K 31/38, A61K 31/40, A61K 31/535, C07D 333/56, C07D 409/00
US Classification:
514443, 514422, 5142315, 548527, 549 58, 544146
Abstract:
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula.