LILLIAN F. PLINER, M.D.
Osteopathic Medicine at Cayuga Way, Short Hills, NJ
License number
New Jersey 25MA04791500
Category
Osteopathic Medicine
Type
Medical Oncology
Address
Address
47 Cayuga Way, Short Hills, NJ 07078
Phone
(973) 972-6257
(973) 972-2384 (Fax)
(973) 972-2384 (Fax)
Professional information
Compositions And Methods For Diagnosis And Treatment Of Breast Cancer
US Patent:
2012029, Nov 22, 2012
Filed:
May 17, 2012
Appl. No.:
13/473938
Inventors:
Pranela Rameshwar - Maplewood NJ, US
Lillian F. Pliner - Short Hills NJ, US
Margarette Bryan - Bloomfield NJ, US
Lillian F. Pliner - Short Hills NJ, US
Margarette Bryan - Bloomfield NJ, US
Assignee:
University of Medicine and Dentistry of New Jersey - Somerset NJ
International Classification:
C12N 5/095, C12Q 1/18, C12Q 1/68, C40B 30/04, G01N 21/76, G01N 21/64
US Classification:
506 9, 435371, 435 723, 435 612, 435 32
Abstract:
The present invention is a population of breast cancer cells with preference for establishing dormancy in bone marrow. The breast cancer cells have characteristics of stem cells and express high levels of Oct4, designated Oct4, but are also not dependent on stem cell gene status. The Oct4cells exhibit functional gap junction intercellular communication with bone marrow stroma, indicating that these cells can establish dormancy and remain resistant to chemotherapy. Also provided by the present invention are a biomarker for metastatic breast cancer, a method for diagnosis and prognosis of breast cancer, and a method for identifying treatments that target dormant metastatic cells.