LIANG NONG
Medical Practice at Timberland Pt Dr, Tampa, FL
License number
Florida 45672
Issued Date
Oct 4, 2013
Effective Date
Oct 4, 2013
Expiration Date
Aug 31, 2018
Category
Health Care
Type
Clinical Laboratory Personnel
Address
Address
10224 Timberland Point Dr, Tampa, FL 33647
Phone
(813) 270-0286
Professional information
Cannabinoid 2 (Cb2) Receptor Gene Promoter And Unique Rna Transcripts In B Cells And Methods Of Use
US Patent:
2014003, Feb 6, 2014
Filed:
Sep 23, 2013
Appl. No.:
14/033938
Inventors:
TRACY SHERWOOD - RIVERVIEW FL, US
LIANG NONG - TAMPA FL, US
CATHY NEWTON - LAND O'LAKES FL, US
LIANG NONG - TAMPA FL, US
CATHY NEWTON - LAND O'LAKES FL, US
International Classification:
C12Q 1/68
US Classification:
435 612
Abstract:
Cannabinoid receptor 2 (CB) is expressed in B lymphocytes and is involved in immune regulation. Mouse splenic B cells express three CBtranscripts utilizing two different first exons. Human peripheral blood B cells express one CBtranscript utilizing one first exon. Alignment of sequenced RACE products to either the mouse or human genome reveals that isolated transcripts contain previously unidentified transcriptional start sites (TSS). B cells from mouse and human preferentially express one transcript, exon 1a in mouse and exon 1 in human. Multiple CBTSSs are utilized in mouse splenic B cells and one TSS in human peripheral blood B cells. The defining of the receptor gene TSSs in these cells provides materials and methods for therapeutically regulating immune function, including antibody isotype switching, using compounds such as inhibitory nucleic acids that down-regulate expression of the B cell CBgene (e.g., RNAi molecules).
Cannabinoid 2 (Cb2) Receptor Gene Promoter And Unique Rna Transcripts In B Cells And Methods Of Use
US Patent:
2011009, Apr 21, 2011
Filed:
Aug 19, 2010
Appl. No.:
12/859744
Inventors:
Thomas W. Klein - Tampa FL, US
Tracy Sherwood - Riverview FL, US
Liang Nong - Tampa FL, US
Cathy Newton - Land O'Lakes FL, US
Tracy Sherwood - Riverview FL, US
Liang Nong - Tampa FL, US
Cathy Newton - Land O'Lakes FL, US
Assignee:
UNIVERSITY OF SOUTH FLORIDA - Tampa FL
International Classification:
A61K 31/7105, C07H 21/04, C12N 5/00, C12Q 1/68, C12N 15/63, A61P 37/00, A61P 11/06, C12Q 1/02
US Classification:
514 44 A, 536 241, 536 235, 435375, 536 245, 435 6, 4353201, 435455, 435 29
Abstract:
Cannabinoid receptor 2 (CB) is expressed in B lymphocytes and is involved in immune regulation. Mouse splenic B cells express three CBtranscripts utilizing two different first exons. Human peripheral blood B cells express one CBtranscript utilizing one first exon. Alignment of sequenced RACE products to either the mouse or human genome reveals that isolated transcripts contain previously unidentified transcriptional start sites (TSS). B cells from mouse and human preferentially express one transcript, exon 1a in mouse and exon 1 in human. Multiple CBTSSs are utilized in mouse splenic B cells and one TSS in human peripheral blood B cells. The defining of the receptor gene TSSs in these cells provides materials and methods for therapeutically regulating immune function, including antibody isotype switching, using compounds such as inhibitory nucleic acids that down-regulate expression of the B cell CBgene (e.g., RNAi molecules).