LIANG FANG, D.M.D.
Dentist at Belair Rd, Baltimore, MD

8288346, Oct 16, 2012

Oct 9, 2009

12/576851

Paul A. Welling - Baltimore MD, US
Liang Fang - Halethorpe MD, US

University of Maryland, Baltimore - Baltimore MD

A61K 38/16, A61K 38/00, C07K 14/435

514 174, 514 11, 514 212, 530350

The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of treating or preventing hyperkalemia have been discovered that include administering to a patient who is at risk of developing hyperkalemia or who has hyperkalemia, a therapeutically effective amount of an agent that blocks the interaction of the ROMK internalization sequence with ARH protein, thereby preventing or reducing ARH-induced endocytosis of ROMK.