Inventors:
George Eisenbarth - Golden CO, US
Li Zhang - Aurora CO, US
John Kappler - Denver CO, US
Brian Stadinski - N. Easton MA, US
International Classification:
A61K 39/395, A61P 3/10, C07K 16/18, A61K 39/385, A61P 37/04
US Classification:
4241391, 4241301, 4241931, 5303873, 5303879, 5303881, 5303891
Abstract:
The present invention is directed to therapeutic compositions and methods for the prevention or treatment of autoimmune diseases, comprising molecules that disrupt or prevent the assembly of the trimolecular complex required for the T cell immune response comprising the autoantigen, the MHC class II molecule, and the T cell receptor implicated in the autoimmune disease.