Inventors:
Kuo-Hsiung Lee - Chapel Hill NC, US
Li Lin - Chapel Hill NC, US
Charles C-Y Shih - Solana Beach CA, US
Ching-Yuan Su - San Diego CA, US
Junko Ishida - Tokyo, JP
Hironori Ohtsu - Matsubara, JP
Hideji Itokawa - Chapel Hill NC, US
Chawnshang Chang - Pittsford NY, US
Assignee:
The University of North Carolina - Chapel Hill NC
The University of Rochester Medical Center - Rochester NY
Androscience Corporation - San Diego CA
International Classification:
A61K 31/341, C07C 49/217, A61K 31/12, C07C 205/06, A61P 35/04, A61P 17/14, A61P 25/00, A61P 17/10, A61P 15/00, A61P 35/00, C12N 5/00, A61K 31/122, C07D 407/06
US Classification:
514473, 568325, 514679, 549473, 514676, 568306, 435375
Abstract:
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.