Inventors:
Yong Sung Choi - New Orleans LA
Li Li - New Orleans LA
Assignee:
Ochsner Clinic Foundation - New Orleans LA
International Classification:
C12P 2108
US Classification:
53038873, 5303879, 5303888, 5303873, 4353431, 435344, 435346
Abstract:
The present invention provides monoclonal antibodies which interfere with the interactions between FDCs and B cells, thereby suppressing the proliferation and/or differentiation of B cells in lymphoid follicles. The monoclonal antibodies of the present invention are useful for treating follicular lymphomas, multiple myeloma as well as autoimmune diseases.