LEWIS JOSEPH LEESON
Pharmacy in Roseland, NJ

4758427, Jul 19, 1988

Jan 20, 1987

7/006297

Lewis J. Leeson - Roseland NJ

Ciba-Geigy Corporation - Ardsley NY

A61K 1700, A61K 3147

424 80

The absorption of orally administered substantially aqueous insoluble psychoactive 2-aryl-pyrazolo [4,3-C] quinolin-3-ones of the formula ##STR1## where R" is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo or trifluoromethyl, and R' is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo, trifluoromethyl, nitro, amino, mono- or di-lower alkylamino, mono- or di-lower alkylcarbamoylamino, mono- or di-lower alkylcarbamoyloxy or cyano, or a pharmaceutically acceptable salt thereof, is enhanced by administering the same in the form of a storage stable solid molecular dispersion of polyvinylpyrrolidone.

4765985, Aug 23, 1988

May 20, 1987

7/051781

Lewis J. Leeson - Roseland NJ

Ciba-Geigy Corporation - Ardsley NY

A61F 1302, A61K 970

424449

A device for the transdermal administration of a drug for the treatment of memory impairment comprising: (a) a drug impermeable backing layer; (b) a drug permeable rate controlling membrane sealed to one side of said backing layer as to define at least one drug reservoir compartment therebetween; (c) an adhesive layer; (d) a drug or composition thereof within said hollow drug reservoir; said drug comprising a memory improving effective amount of a compound having the formula ##STR1## wherein X. sub. 1, X. sub. 2, X. sub. 3, X. sub. 4, independently represent --H or lower alkyl; said composition comprising said drug and at least one pharmaceutically acceptable adjunct; whereby said drug is delivered in a controlled, continuous manner to a patient to which said device has been applied.

4680172, Jul 14, 1987

Mar 5, 1985

6/708466

Lewis J. Leeson - Roseland NJ

Ciba-Geigy Corporation - Ardsley NY

A61F 702

424449

A device for the transdermal administration of a drug for the treatment of memory impairment comprising: (a) a drug impermeable backing layer; (b) a drug permeable rate controlling membrane sealed to one side of said backing layer as to define at least one drug reservoir compartment therebetween; (c) an adhesive layer; (d) a drug or composition thereof within said hollow drug reservoir; said drug comprising a memory improving effective amount of a compound having the formula ##STR1## wherein R. sub. 1 is OH, lower alkoxy, or NR. sub. 3 R. sub. 4 ; and each of R. sub. 2, R. sub. 3 and R. sub. 4 is independently H or lower alkyl; said composition comprising said drug and at least one pharmaceutically acceptable adjunct; whereby said drug is delivered in a controlled, continuous manner to a patient to which said device has been applied.

4965074, Oct 23, 1990

Aug 15, 1988

7/232266

Lewis J. Leeson - Roseland NJ

Ciba-Geigy Corporation - Ardsley NY

A61K 900, A61K 970, A61K 31465, A61F 1300

424449

A method for the treatment of memory impairment, especially Senile Dementia of the Alzheimer's Type, by administering to a patient in need thereof an effective amount of nicotine or an N-lower alkyl analog thereof by the transdermal route.

4137300, Jan 30, 1979

Jun 14, 1977

5/806424

Pravin Sheth - Springfield NJ
Lewis J. Leeson - Roseland NJ

Ciba-Geigy Corporation - Ardsley NY

A61K 924, A61K 938, A61K 942

424 21

By incorporating solid drug substances into mixtures of higher alkanols and/or alkanoic acids melting above 25. degree. C, forming granules thereof and covering them with a prolamine, a pharmaceutical dosage form is obtained, which slowly and evenly releases the drug within the gastrointestinal tract of a mammal.