Inventors:
Carmelle Remillard - San Diego CA, US
Lewis J. Rubin - La Jolla CA, US
Ying Yu - Lake Forest CA, US
Jason X.J. Yuan - San Diego CA, US
International Classification:
C12Q 1/68, A61K 39/395, A61K 31/7088, A61K 38/02, C07H 21/02, C12N 15/63, C12N 15/11, C07K 16/00, C07K 2/00, G01N 33/53
US Classification:
4241301, 435 6, 514 44, 514 2, 536 245, 5303871, 5303881, 4353201, 436501
Abstract:
The present invention relates to compositions related to a polynucleotide encoding a transient receptor potential cation gene. Also disclosed is the use of this polynucleotide, its homologs, fragments, variants and its resultant polypeptides in the diagnosis, prevention and treatment of disease, particularly idiopathic pulmonary arterial hypertension (IPAH). This invention also teaches the use of these polynucleotides and polypeptides as assays for drug discovery and therapies.