Inventors:
Dan E. Berkowitz - Baltimore MD, US
Sungwoo Ryoo - Timonium MD, US
Artin A. Shoukas - Baltimore MD, US
Gaurav Gupta - McLean VA, US
Lewis Romer - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 31/7088, C12Q 1/34, C12N 5/02, C12N 9/99, G01N 33/573
US Classification:
514 44 R, 435 18, 435375, 435184, 435 74
Abstract:
The instant invention provides methods and compositions for the treatment of. atherosclerotic disease. Specifically, the invention provides methods and compositions for modulating the activity of Arginase II, the production of Arginase II or the amount of free Arginase II for the treatment of atherosclerotic disease.