DR. LEROY ELAZAR RABBANI, M.D.
Osteopathic Medicine at Fort Washington Ave, New York, NY

5854223, Dec 29, 1998

Jul 11, 1996

8/678234

Cy Stein - New City NY
LeRoy Rabbani - New York NY

The Trustees of Columbia University in the City of New York - New York NY

A61K 4800

514 44

This invention provides methods of inhibiting proliferation, migration and heterotypic adhesion of vascular smooth muscle cells which comprise contacting the vascular smooth muscle cells with an amount of a phosphorothioate oligonucleotide moiety effective to inhibit the proliferation, migration or heterotypic adhesion of the vascular smooth muscle cells. This invention provides methods of inhibiting neointimal formation after balloon injury, percutaneous transluminal coronary angioplasty restenosis, and coronary artery stent restenosis in a subject which comprise administering to the subject an amount of a phosphorothioate oligonucleotide moiety effective to inhibit neointimal formation, percutaneous transluminal coronary angioplasty restenosis, or coronary artery stent restenosis in the subject. This invention further provides pharmaceutical compositions effective for treating the conditions recited above.