LEONARD S GIRSH
Medical Practice in Naples, FL

2007023, Oct 4, 2007

Nov 2, 2006

11/592530

Leonard Girsh - Naples FL, US

ImmunoPath Profile, Inc. - Naples FL

A61K 35/20

424535000

The present invention relates to a non-invasive medical therapy and a composition for avoiding organ transplantation, or controlling biological rejection of transplanted organs, or treating organs under consideration for replacement by transplant, and otherwise treating aged, diseased and/or abnormal tissues and/or organs. More specifically, the non-invasive medical therapy involves administering to a patient an elemental nutritional feeding comprising a free amino acid profile simulating and/or replicating a targeted diseased or transplanted tissue and/or organ. The subject invention provides methods of inactivating reactive component epitopes of moieties pathogenic substances or producing immunogenic compositions containing pathogenic substances comprising contacting pathogenic substances, or compositions containing pathogenic substances, with super critical carbon dioxide or liquid nitrogen. Similar benefits are produced using high HLB surfactants also reducing carcinogenic factors. In various embodiments, the pathogenic reactive components, epitopes, moieties or substances are inactivated and processed into immunogenic compositions. The subject invention also provides oral mucosal delivery systems for the subject therapeutic compositions and/or medications, and/or vaccines that avert the need for parenteral administration in the medical and veterinary fields.

2011021, Sep 1, 2011

Feb 4, 2011

13/021487

LEONARD S. GIRSH - Naples FL, US

IMMUNOPATH PROFILE, INC. - Naples FL

A61B 5/055, A61B 6/00, A61B 8/00, A61B 6/03, A61K 35/34, A61P 29/00, A61P 37/04

600410, 600476, 600437, 378 4, 424548

The subject invention pertains to a synthetic biopharmaceutical non-invasive medical therapy, administered locally or systemically and compositions for treating aged, diseased or abnormal tissues and organs. The composition and methods of the invention may also be used to augment the treatment of multiple diseases and disorders of the body. The present invention involves administering to a patient a therapeutic formulation comprising a free L-amino acid non-chiral glycine profile, simulating or replicating the proteins normally present in healthy tissue that is now diseased or transplanted tissue. The invention also relates to therapy involving administration of therapeutic formulations comprising free L-amino acids in which the molar ratios of the amino acids correspond to the ratios of components such as amino components in a key cell or molecular embryology systemic as a medication or a biochemical and biophysical medication and essence of cell membrane polar surface active lipid equivalent that is useful for treating a disease. Simultaneous administration of the compositions are able to work synergistically to restructure diseased tissue and organs. Also disclosed are devices and methods for diagnosing diseased or damaged tissue by observance of tissue biomarkers made visible by direct application of polarizing light to a tissue sample. Birefringence light from damaged or diseased tissue can be analyzed and compared with normal tissue birefringence to diagnose diseased or damaged tissue or diagnose a tissue deficiency.

2009027, Nov 5, 2009

May 15, 2009

12/466850

LEONARD S. GIRSH - Naples FL, US

Immunopath Profile, Inc. - Naples FL

A61K 35/74, A61K 35/12, A61K 35/34

424 933, 424520, 424548

Synthetic Stem Cell-like Tissue Healing and Regeneration Medication with Anti-inflammatory, Protein Synthesis, Enzyme Deficiency Activation and Genetic Therapy, and Anti-cancer Agent derived from a series of inventions that include these products of Biomolecular Engineering, Drug Discovery from a Biologic Periodic Table of Applied Biochemistry and Biophysics. Tissue has a self healing effect promoting tissue healing and tissue regeneration. Not only does it maintain good health but also it has been observed that the patient's blood is withdrawn from the patient and applied to the ulcer has healing qualities. Cartilage placed in a wound promotes and accelerates wound healing. The anabolic biochemical and biophysical equivalent of tissue has been found in these embodiments to have the same pharmacologic qualities, when devoid of genetic DNA mismatch and other catabolic factors including the catabolic effects of microorganism overgrowth that lacks pro-biotic qualities. The healing efficacy of these tissue components gives us further appreciation of the protective action of human tissue over and above and other than the immune protective system or perhaps an integral component part of the immune system.

2012014, Jun 7, 2012

Feb 8, 2012

13/368672

Leonard S. Girsh - Naples FL, US

IMMUNOPATH PROFILE, INC. - NAPLES FL

A61K 35/32, A61K 31/728, A61K 38/39, A61K 36/87, A61P 21/06, A61K 33/30, A61P 29/00, A61P 1/00, A61P 35/00, A61K 31/737, A61K 33/04

424548, 514 54, 514 172, 514 133, 424766, 424702, 424643

A composition for treating damaged tissue and promoting healthy tissue growth, healing and tissue regeneration, wherein said composition comprises an extracellular matrix compound, a surface-active lipid, one or more enantiomerically pure L-amino acids or glycine, a hydrophilic surfactant with a high HLB, as well as vitamins, minerals or trace elements. Not only does it maintain good health, but the components are non-intrusive, bio-safe, non-coalescent and can mimic normally occurring stem-cells within a body. When applied to diseased tissues, the subject compositions can stimulate, facilitate, and accelerate protein synthesis for the regeneration of diseased organs and tissues. The healing efficacy of these tissue components gives us further appreciation of the protective action of human tissue over and above and other than the immune protective system or perhaps an integral component part of the immune system.

7718824, May 18, 2010

Aug 26, 2005

11/212530

Leonard S. Girsh - Naples FL, US

Immunopath Profile, Inc. - Naples FL

A61K 38/16, A61K 31/715, G01N 33/92

562433, 514 8, 514 54, 530356, 530395, 436 71, 424 91

The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid; wherein the composition is administered to a mammal suffering from severe tissue damage. The invention further relates to a composition and uses thereof comprising a mixture of one or more free L-amino acids in which the molar ratio of the free L-amino acids corresponds to the molar ratio of amino components in a mammalian tissue protein; and at least one essential lipid.

7622144, Nov 24, 2009

Sep 25, 2006

11/526304

Leonard S. Girsh - Naples FL, US

Immunopath Profile, Inc. - Naples FL

A23C 9/20

426580, 426474, 426587, 426588

Common allergenic foods are made hypoallergenic by treatment with super critical fluid or critical liquid gas such as super critical carbon dioxide or liquid nitrogen. The treatment of foods with liquid nitrogen or super critical carbon dioxide also enhances the functionality of fat, so that the total fat in the food can be reduced while retaining the good taste of the food. Compositions and methods for the oral delivery of a medicament or vitamin are also provided.

2007003, Feb 15, 2007

Aug 9, 2006

11/501380

Leonard Girsh - Naples FL, US

A61K 31/198, A61K 31/685, A61K 47/00

514078000, 514561000, 514773000, 514785000

Anabolic compositions can be administered to patients with chronic diseases, or who suffer from conditions precipitated by such diseases or long term treatment regimes. The compositions comprise at least one surfactant wherein the total concentration of surfactant in the composition is greater than 1% (w/w or w/v), and can cause weight gain in chronic disease patients as well as reduce or eliminate other disease symptoms or conditions. The anabolic compositions can also provide therapeutic benefit in patients who are candidates for, or who have undergone, organ or tissue transplant procedures.

2005026, Nov 24, 2005

Mar 7, 2005

11/073514

Leonard Girsh - Naples FL, US

A61K045/00, A61K038/46, A61K031/198

424093450, 514561000, 424094600

This invention relates to a composition and method for treating diseased or damaged tissues. The composition provides anabolic components and other components that mimic conditions of healthy human tissue, promote tissue regeneration and alleviate disease states. The composition is a medicament having a first component comprising a plurality of L amino acids, a second component comprising at least one extracellular matrix compound, a third component comprising at least one polar surface active lipid, a fourth component comprising vitamins, minerals, and trace elements, and a fifth component comprising a probiotic composition.

2012004, Feb 16, 2012

Oct 24, 2011

13/279815

Leonard S. Girsh - Naples FL, US

IMMUNOPATH PROFILE, INC. - Naples FL

A61K 31/4172, A61K 35/32, A61P 17/00, A61P 27/02, A61P 1/16, A61P 1/00, A61P 13/12, A61P 9/00, A61P 11/00, A61P 5/00, A61P 19/02, A61P 21/00, A61P 25/00, A61P 29/00, A61P 7/00, A61P 31/18, A61K 38/39, A61K 33/30, A61K 31/726, A61K 31/728, A61K 31/715

424548, 514 62, 514400, 514 165, 424643, 514 61

The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid; wherein the composition is administered to a mammal suffering from severe tissue damage. The invention further relates to a composition and uses thereof comprising the mixture of one or more free L-amino acids in which the molar ratio of the free L-amino acids corresponds to the molar ratio of amino components in a mammalian tissue protein; and at least one essential lipid.