DR. LEONARD I ZON, MD
Osteopathic Medicine in Boston, MA
License number
Massachusetts 55881
Category
Osteopathic Medicine
Type
Hematology & Oncology
Address
Address
2
300 Longwood Ave Research Building FLOOR 7, Boston, MA 02115
6 Frost Cir, Wellesley, MA 02482
6 Frost Cir, Wellesley, MA 02482
Phone
(617) 919-2069
(781) 431-9123
(781) 431-9123
Personal information
See more information about LEONARD I ZON at radaris.comName
Address
Phone
6 Frost Cir, Wellesley, MA 02482
Wellesley, MA
6 Frost Cir, Wellesley, MA 02482
6 Frost Cir, Wellesley, MA 02482
29 Park Vale Ave, Allston, MA 02134
Professional information
Methods For Treatment Of Melanoma
US Patent:
2014003, Jan 30, 2014
Filed:
Feb 8, 2012
Appl. No.:
13/983090
Inventors:
Leonard Zon - Wellesley MA, US
Richard M. White - Cambridge MA, US
Richard M. White - Cambridge MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 31/437, A61K 31/277, A61K 31/42
US Classification:
514300, 435 32, 435 612
Abstract:
The present invention is directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods herein are directed to screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma.
Two Sterile-20 Kinase-Like Proteins And Methods Of Use Thereof
US Patent:
6524833, Feb 25, 2003
Filed:
Oct 10, 2000
Appl. No.:
09/685462
Inventors:
Leonard I. Zon - Wellesley MA
Sadhana Agarwal - Cambridge MA
Jennifer Best - Cambridge MA
Brenda Vail - Dedham MA
Sadhana Agarwal - Cambridge MA
Jennifer Best - Cambridge MA
Brenda Vail - Dedham MA
Assignee:
Childrens Medical Center Corporation - Boston MA
International Classification:
C12N 912
US Classification:
435194, 4352523, 4353201, 435325, 435 6, 536 232
Abstract:
Described herein are novel members of the Sterile 20 family of serine/threonine protein kinases, including nucleic acid sequences and amino acid sequences.
Method Of Enhancing Proliferation And/Or Hematopoietic Differentiation Of Stem Cells
US Patent:
7427603, Sep 23, 2008
Filed:
Sep 18, 2003
Appl. No.:
10/528808
Inventors:
Leonard I. Zon - Wellesley MA, US
Alan J. Davidson - West Roxbury MA, US
George Q. Daley - Weston MA, US
Alan J. Davidson - West Roxbury MA, US
George Q. Daley - Weston MA, US
Assignee:
The Children's Medical Center Corporation - Boston MA
International Classification:
A61K 31/713
US Classification:
514 44, 435455, 435377
Abstract:
The present invention provides a method for enhancing the proliferation and/or hematopoietic differentiation and/or maintenance of mammalian stem cells. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy. The method of the present invention comprises increasing the intracellular level of a cdx in stem cells, including hematopoietic stem cells, in culture, either by providing an exogenous cdx protein to the cell, or by introduction into the cell of a genetic construct encoding a cdx. The cdx is selected from the cdx family and includes cdx1, cdx2, or cdx4. The cdx may be a wild type protein appropriate for the species from which the cells are derived, or a mutant form of the protein.
Ferroportin1 Nucleic Acids And Proteins
US Patent:
7166448, Jan 23, 2007
Filed:
Nov 17, 2000
Appl. No.:
09/715927
Inventors:
Leonard I. Zon - Wellesley MA, US
Adriana Donovan - Boston MA, US
Adriana Donovan - Boston MA, US
Assignee:
Children's Medical Center Corproation - Boston MA
International Classification:
C12N 15/00, C12N 15/85, C12N 9/00, C07H 21/04, C07K 14/00, C12P 19/34
US Classification:
435 912, 536 231, 536 234, 536 235, 536 2431, 530350, 435325, 435183, 435 6, 435 691
Abstract:
Positional cloning has been carried out to identify the gene responsible for the hypochromic anemia of the zebrafish mutant weissherbst. The gene, ferroportin1, encodes a novel multiple-transmembrane domain protein, expressed in the yolk sac. Zebrafish ferroportin1 is required for the transport of iron from maternally-derived yolk stores to the circulation, and functions as an iron exporter when expressed in oocytes. Human and mouse homologs of the ferroportin1 gene have been identified. The invention includes isolated polynucleotides, vectors and host cells comprising nucleotide sequences encoding Ferroportin1 proteins and variants thereof, including those having iron transport function. The invention also includes polypeptides encoded by ferroportin1 genes and variants of such polypeptides, and fusion polypeptides comprising a Ferroportin1 or a portion thereof. Methods to produce a Ferroportin1, methods to produce antibodies to a Ferroportin1 and methods to identify agents binding to a Ferroportin1, which can be inhibitors or enhancers of Ferroportin1 iron transport activity, are also described. Inhibitors of Ferroportin1 activity can be used in a therapy for hemochromatosis.
Methods For Promoting Hsc Self-Renewal
US Patent:
2012018, Jul 26, 2012
Filed:
Mar 27, 2012
Appl. No.:
13/431563
Inventors:
Leonard I. Zon - Wellesley MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Trista E. North - Newton Center MA, US
Wolfram Goessling - Chestnut Hill MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
International Classification:
A61K 35/12, A61P 7/06, A61P 35/02, A61P 35/00
US Classification:
424 937
Abstract:
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E(PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Method Of Screening Compounds
US Patent:
2005015, Jul 14, 2005
Filed:
Dec 17, 2002
Appl. No.:
10/499234
Inventors:
Leonard Zon - Wellesley MA, US
Howard Stern - Newton MA, US
Ryan Murphey - Brookline MA, US
Howard Stern - Newton MA, US
Ryan Murphey - Brookline MA, US
International Classification:
A01K067/027, A61K049/00
US Classification:
800003000, 800020000
Abstract:
The present invention is directed to a novel, target-blind approach to drug discovery. The concept is to model human phenotypes in a teleost, such as a zebrafish, and then screen compounds, e.g., small molecules, for their ability to alter the phenotype. Because the screen is performed with a whole vertebrate organism and uses a phenotype as the output, the need to first identify target genes is eliminated. This approach is powerful because a single screen can theoretically detect drugs affecting any target relevant to the phenotype being observed, even if those targets are not yet characterized.
Tbc1 Gene And Uses Thereof
US Patent:
5700927, Dec 23, 1997
Filed:
Dec 23, 1994
Appl. No.:
8/363300
Inventors:
Leonard Zon - Wellesley MA
Paul Richardson - Boston MA
Paul Richardson - Boston MA
Assignee:
The Children's Medical Center Corporation - Boston MA
International Classification:
C12N 1512, C07K 14475
US Classification:
536 235
Abstract:
Disclosed is a substantially pure DNA encoding a Tbc1 polypeptide; a substantially pure Tbc1 polypeptide; and methods of using such DNA to express Tbc1 in leukemic stem cells and treat certain leukemias. Also disclosed are methods for diagnosing other leukemias and spermatogenesis disorders by assaying for Tbc1 expression.
Braf Expression In Zebrafish And Uses Thereof
US Patent:
2008007, Mar 20, 2008
Filed:
May 9, 2005
Appl. No.:
11/596146
Inventors:
Leonard Zon - Wellesley MA, US
E. Patton - Oxford, GB
E. Fisher - Newton MA, US
Hans Widlund - Boston MA, US
E. Patton - Oxford, GB
E. Fisher - Newton MA, US
Hans Widlund - Boston MA, US
Assignee:
Children's Medical Center Corporation - Boston MA
International Classification:
A01K 67/00, G01N 33/00
US Classification:
800003000, 800010000
Abstract:
The present invention discloses a transgenic zebrafish that express activated BRAF specifically in melanocytes and its uses in screening for agents that can be used to treat melanomas or screening for agents that aggravate or induce melanomas.
Method For Identifying Genes Involved In Cell Proliferation
US Patent:
6943025, Sep 13, 2005
Filed:
Jan 10, 2001
Appl. No.:
09/758007
Inventors:
Leonard I. Zon - Wellesley MA, US
James Amatruda - Cambridge MA, US
Jennifer Shepard - Brookline MA, US
James Amatruda - Cambridge MA, US
Jennifer Shepard - Brookline MA, US
Assignee:
Children's Medical Center Corporation - Boston MA
International Classification:
C12N015/09, C12N015/85, C12Q001/68, C12Q033/53, A01K067/027
US Classification:
435440, 435 6, 435 71, 435 8, 800 8, 800 9, 800 10, 800 13, 800 20, 800 21, 800 22
Abstract:
The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming and costly maintenance of animals. The invention provides a tool to identify functional characteristics of a protein without prior knowledge of the gene sequence. After identification of the mutant gene in the fish system, the nucleic acid sequence of the gene can be used for identifying a homologue of the gene in another species, for example, in humans.
Expression Cloning Using A Tagged Cdna Library
US Patent:
2005022, Oct 13, 2005
Filed:
Feb 4, 2005
Appl. No.:
11/051938
Inventors:
Leonard Zon - Wellesley MA, US
Sadhana Agarwal - Cambridge MA, US
Sadhana Agarwal - Cambridge MA, US
Assignee:
Children's Medical Center Corporation - Boston MA
International Classification:
C12Q001/68, C12N015/74
US Classification:
435006000, 435471000
Abstract:
Methods of expression cloning where a cDNA construct expresses a tagged polypeptide for a biochemical activity of interest are described.