LELAND SHAPIRO, MD
Osteopathic Medicine at 16 Ave, Denver, CO
License number
Colorado 35470
Category
Osteopathic Medicine
Type
Infectious Disease
Address
Address
12605 E 16Th Ave, Denver, CO 80045
Phone
(720) 848-0000
(303) 493-7000
(303) 493-7000
Personal information
See more information about LELAND SHAPIRO at radaris.comName
Address
Phone
8765 E 29Th Pl, Denver, CO 80238
9123 E Mississippi Ave APT 1-3, Denver, CO 80247
Denver, CO
4200 9Th Ave, Denver, CO 80220
9123 Mississippi Ave, Denver, CO 80247
Organization information
See more information about LELAND SHAPIRO at bizstanding.comLeland Shapiro MD
1055 Clermont St, Denver, CO 80220
Industry:
Internist
Phone:
(303) 393-2837 (Phone)
Leland Shapiro
Professional information
Dr. Leland Shapiro - MD (Doctor of Medicine)
Hospitals:
1055 Clermont St, Denver 80220
University of Colorado Hospital - Anschutz Inpatient Pavilion
12605 East 16Th Avenue Dr, Aurora 80045
1055 Clermont St, Denver 80220
University of Colorado Hospital - Anschutz Inpatient Pavilion
12605 East 16Th Avenue Dr, Aurora 80045
University of Colorado Hospital - Anschutz Inpatient Pavilion
12605 East 16Th Avenue Dr, Aurora 80045
1055 Clermont St, Denver 80220
University of Colorado Hospital - Anschutz Inpatient Pavilion
12605 East 16Th Avenue Dr, Aurora 80045
Education:
Medical Schools
University Of Massachusetts Medical School
Graduated: 1986
University Of Massachusetts Medical School
Graduated: 1986
Inhibitors Of Serine Protease Activity, Methods And Compositions For Treatment Of Nitric Oxide Induced Clinical Conditions
US Patent:
2004022, Nov 4, 2004
Filed:
May 2, 2003
Appl. No.:
10/427929
Inventors:
Leland Shapiro - Denver CO, US
International Classification:
A61K031/4245
US Classification:
514/364000
Abstract:
A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are -antitrypsin and synthetic drugs mimicking some or all of the actions of -antitrypsin.
Inhibitors Of Serine Protease Activity, Methods And Compositions For Treatment Of Viral Infections
US Patent:
6849605, Feb 1, 2005
Filed:
Mar 3, 2000
Appl. No.:
09/518098
Inventors:
Leland Shapiro - Denver CO, US
Assignee:
The Trustees of University Technology Corporation - Boulder CO
International Classification:
C07K 506
US Classification:
514 19, 514 18, 530331
Abstract:
A novel method of treating and preventing viral infection is provided. In particular a method of blocking viral infection facilitated by a serine proteolytic (SP) activity is disclosed, which consists of administering to a subject suffering or about to suffer from viral infection a therapeutically effective amount of a compound having a serine protease inhibitory or serpin activity. Among compounds are α-antitrypsin (AAT), peptide derivatives from the carboxyterminal end of AAT, and man-made, synthetic compounds mimicking the action of such compounds. The preferred viral infections include retroviral infection such as human immunodeficiency virus (HIV) infection.
Inhibitors Of Serine Protease Activity Methods And Compositions For Treatment Of Nitric Oxide-Induced Clinical Conditions
US Patent:
2004022, Nov 4, 2004
Filed:
Sep 25, 2003
Appl. No.:
10/669251
Inventors:
Leland Shapiro - Denver CO, US
International Classification:
A61K031/433, A61K031/4245
US Classification:
514/362000, 514/364000
Abstract:
A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are -antitrypsin and synthetic drugs mimicking some or all of the actions of -antitrypsin.
Methods And Compositions For Treatment Of Nitric Oxide-Induced Clinical Conditions
US Patent:
2009029, Dec 3, 2009
Filed:
Apr 21, 2009
Appl. No.:
12/427075
Inventors:
Leland Shapiro - Denver CO, US
Assignee:
Bio Holding, Inc. - Wilson NC
International Classification:
A61K 38/14, A61P 29/00, A61P 11/00, A61P 9/00
US Classification:
514 8
Abstract:
The present invention provides compositions and methods for modulating cellular nitric oxide (NO) production and for treating a clinical condition associated therewith.
Methods And Compositions For Treatment Of Graft Rejection And Promotion Of Graft Survival
US Patent:
2012004, Feb 23, 2012
Filed:
Apr 22, 2011
Appl. No.:
13/092825
Inventors:
Eli C. Lewis - Be'er Sheva, IL
Charles A. Dinarello - Boulder CO, US
Leland Shapiro - Denver CO, US
Charles A. Dinarello - Boulder CO, US
Leland Shapiro - Denver CO, US
International Classification:
A61K 39/00, A01N 1/02, C12N 5/02, A61P 37/06, A61P 3/10, A61P 29/00, A61P 17/02, A61P 37/02, A61K 35/12, A61K 38/00
US Classification:
4241841, 424 937, 435 11, 435375, 514 11, 514 201
Abstract:
Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In certain embodiments, compositions and methods relate to inhibition of graft rejection and promotion of graft survival. Thus, the invention relates to modulation of cellular activities, including graft rejection, promotion of graft survival, graft versus host rejection, islet cell preservation and conditions commonly associated with graft rejection. Other embodiments relate to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease and inducers of other alpha1-antitrypsin activities.
Methods And Compositions For Treatment Of Viral Infections
US Patent:
2007015, Jul 5, 2007
Filed:
Dec 12, 2005
Appl. No.:
11/298629
Inventors:
Leland Shapiro - Denver CO, US
Colm King - Delray Beach FL, US
Harvey Katz - Delray Beach FL, US
Colm King - Delray Beach FL, US
Harvey Katz - Delray Beach FL, US
International Classification:
A61K 31/7076
US Classification:
514043000
Abstract:
A novel method of treating and preventing viral diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of viral infections and the diseases associated with such viral infections. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made compositions comprising a substance exhibiting Tubercin and/or SSM activity or a functional derivative thereof.
Compositions And Methods For Treating Actin-Mediated Medical Conditions
US Patent:
2009022, Sep 10, 2009
Filed:
Dec 4, 2006
Appl. No.:
11/719200
Inventors:
Leland Shapiro - Denver CO, US
Gregory Pott - Westminster CO, US
Gregory Pott - Westminster CO, US
Assignee:
The Regents of the University of Colorado - Boulder CO
International Classification:
A61K 38/08
US Classification:
514 17
Abstract:
The present invention provides a method for treating a subject an actin-mediated medical condition by administering to the subject an actin modulator. In some embodiments, the actin-mediated medical condition is an intracellular actin-mediated medical condition. In other embodiments, the actin-mediated medical condition is a cellular-surface actin mediated medical condition.
Methods And Compositions For Islet Cell Preservation
US Patent:
2012004, Feb 23, 2012
Filed:
Apr 22, 2011
Appl. No.:
13/092823
Inventors:
Eli C. Lewis - Be'er Sheva, IL
Charles A. Dinarello - Boulder CO, US
Leland Shapiro - Denver CO, US
Charles A. Dinarello - Boulder CO, US
Leland Shapiro - Denver CO, US
International Classification:
A61K 35/12, A61P 1/18, A61P 29/00, C12N 5/02, A61P 3/10
US Classification:
424 937, 435375, 435374
Abstract:
Embodiments of the present invention illustrate methods of treating and preventing transplantation and side effects associated with transplantation. In particular, the present invention relates to compositions and methods for inhibition of graft rejection and promotion of graft survival. Thus, the invention relates to modulation of cellular activities, including graft rejection, promotion of graft survival, graft versus host rejection and conditions commonly associated with graft rejection. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease and inducers of other alpha 1-antitrypsin activities.
Methods And Compositions For Treating Diabetes
US Patent:
2012004, Feb 16, 2012
Filed:
Oct 25, 2011
Appl. No.:
13/281311
Inventors:
Leland Shapiro - Denver CO, US
International Classification:
A61K 38/17, A61P 43/00
US Classification:
514 189
Abstract:
The instant invention provides a method of treating an animal suffering a disease characterized by excessive apoptosis by administering a therapeutically effective amount of at least one serine protease inhibitor and thereafter monitoring a decrease in apoptosis. The inhibitor of the invention includes α-antitrypsin or an α-antitrypsin-like agent, including, but not limited to oxidation-resistant variants of α-antitrypsin, and peptoids with antitrypsin activity. The diseases treatable by the invention include cancer, autoimmune disease, sepsis neurodegenerative disease, myocardial infarction, stroke, ischemia-reperfusion injury, toxin induced liver injury and AIDS. The method of the invention is also suitable for the prevention or amelioration of diseases characterized by excessive apoptosis.