Inventors:
Ronald Breslow - Englewood NJ
Sandro Belvedere - New York NY
Leland Gershell - New York NY
Thomas A. Miller - New York NY
Paul A. Marks - Washington CT
Victoria M. Richon - New York NY
Richard A. Rifkind - New York NY
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61K 314709
US Classification:
514314, 514249, 514261, 514266, 514307, 514309, 514311, 514316, 514318, 514354, 514355, 514575, 544277, 544258, 546171, 546141, 546146, 546314, 546316, 562623, 562622
Abstract:
The present invention provides the compound having the formula: wherein each of R and R is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, âOâ, âSâ, âNHâ, or âCH â; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.