LEE W RILEY, MD
Osteopathic Medicine in Berkeley, CA
License number
California G51918
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
530E Li Ka Shing Bldg School Of Public Health, Berkeley, CA 94720
Phone
(510) 642-9200
Professional information
Cellular Delivery Agent
US Patent:
6995255, Feb 7, 2006
Filed:
Mar 4, 2003
Appl. No.:
10/382176
Inventors:
Lee W. Riley - Berkeley CA, US
Sangwei Lu - Berkeley CA, US
Sangwei Lu - Berkeley CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C07H 21/04, C07H 21/02, A61K 39/04
US Classification:
536 237, 424 91, 424 92, 4242341, 4242481, 435 41, 4353201, 435440, 435471, 536 231
Abstract:
One aspect of the present invention relates to a nucleic acid construct which includes a first nucleic acid and a second nucleic acid operatively coupled to the first nucleic acid. The first nucleic acid molecule encodes a first peptide that has the sequence of InvX or another sequence incorporating the 58 amino acid cellular import region of Mce1A and confers on an ability to enter mammalian cells. The second nucleic acid molecule encoding a second peptide. Expression of the nucleic acid construct produces a fusion protein comprising the first peptide coupled to the second peptide. The second peptide may be a therapeutic or a diagnostic peptide. An alternative embodiment of the nucleic acid construct includes the first nucleic acid and an insertion site suitable for incorporation of the second nucleic acid molecule into this version of the construct. The present invention further relates to the fusion protein per se, screening methods for identifying fusion proteins having a protective effect against a pathogen, and therapeutic fusion proteins.
Dna Molecule Conferring On Mycobacterium Tuberculosis Resistance Against Antimicrobial Reactive Oxygen And Nitrogen Intermediates
US Patent:
6177086, Jan 23, 2001
Filed:
Apr 28, 1998
Appl. No.:
9/067626
Inventors:
Lee W. Riley - Berkeley CA
Carl F. Nathan - Larchmont NY
Sabine Ehrt - Berkeley CA
Carl F. Nathan - Larchmont NY
Sabine Ehrt - Berkeley CA
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
A61K 3904, A61K 3902, C12P 2106, C12P 2104, C12N 120
US Classification:
4242481
Abstract:
The present invention relates to a DNA molecule conferring on Mycobacterium tuberculosis resistance to antimicrobial reactive oxygen intermediates and reactive nitrogen intermediates. The protein encoded by this DNA molecule is useful in vaccines to prevent invention by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein or polypeptide is also useful as a therapeutic in treating conditions mediated by the production of reactive oxygen intermediates and nitrogen intermediates.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Leptospira Species
US Patent:
2013023, Sep 5, 2013
Filed:
Apr 24, 2013
Appl. No.:
13/869660
Inventors:
The United States Government represented by the Department of Veterans Affairs - , US
- Rio de Janeiro, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Los Angeles CA, US
Tracy Ann Young - Berkeley CA, US
- Rio de Janeiro, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Los Angeles CA, US
Tracy Ann Young - Berkeley CA, US
Assignee:
The United States Government represented by the Department of Veterans Affairs - Washington DC
Fundação Oswaldo Cruz - FIOCRUZ - Rio de Janeiro
Cornell Research Foundation, Inc. - Ithaca NY
The Regents of the University of California - Oakland CA
Fundação Oswaldo Cruz - FIOCRUZ - Rio de Janeiro
Cornell Research Foundation, Inc. - Ithaca NY
The Regents of the University of California - Oakland CA
International Classification:
C07K 14/20
US Classification:
43525233, 536 237, 4353201
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
Dna Molecule Encoding For Cellular Uptake Of Mycobacterium Tuberculosis And Uses Thereof
US Patent:
6072048, Jun 6, 2000
Filed:
Aug 6, 1997
Appl. No.:
8/907229
Inventors:
Lee W. Riley - Berkeley CA
Assignee:
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
C07H 2104, C07H 1900, A61K 3900, G01N 3353
US Classification:
536 235
Abstract:
The present invention relates to DNA molecules associated with conferring on Mycobacterium tuberculosis an ability to enter mammalian cells. The protein encoded by these DNA molecules are useful in vaccines to prevent infection by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein of the present invention can be associated with various other therapeutic materials, for administration to mammals, particularly humans, to achieve uptake of those materials by such cells.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Leptospira Species
US Patent:
2004005, Mar 25, 2004
Filed:
Sep 19, 2002
Appl. No.:
10/147299
Inventors:
Albert Ko - Salvador, BR
Mitermayer Reis - Salvador, BR
Julio Croda - Salvador, BR
Isadora Siqueira - Salvador, BR
James Matsunaga - Los Angeles CA, US
Lee Riley - Berkeley CA, US
Michele Barocchi - San Francisco CA, US
Tracy Young - Berkeley CA, US
Mitermayer Reis - Salvador, BR
Julio Croda - Salvador, BR
Isadora Siqueira - Salvador, BR
James Matsunaga - Los Angeles CA, US
Lee Riley - Berkeley CA, US
Michele Barocchi - San Francisco CA, US
Tracy Young - Berkeley CA, US
International Classification:
C07K014/20, C12Q001/68, C07H021/04, A61K039/02, C12P021/02, C12N001/21
US Classification:
435/006000, 435/069100, 435/252300, 435/320100, 530/350000, 536/023700, 424/190100
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Species
US Patent:
7718183, May 18, 2010
Filed:
Jan 17, 2006
Appl. No.:
11/332464
Inventors:
Albert I. Ko - Bahia, BR
Mitermayer Galvão Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Los Angeles CA, US
Tracy Ann Young - Oakland CA, US
Mitermayer Galvão Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Los Angeles CA, US
Tracy Ann Young - Oakland CA, US
Assignee:
The United States of America represented by the Department of Veterans Affairs - Washington DC
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz—FIOCRUZ - Rio de Janeiro
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz—FIOCRUZ - Rio de Janeiro
International Classification:
A61K 39/002
US Classification:
4242691, 4241911, 530300, 530350
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Species
US Patent:
8445658, May 21, 2013
Filed:
Jun 15, 2012
Appl. No.:
13/525157
Inventors:
Albert I. Ko - Salvador, BR
Mitermayer Galvão Reis - Salvador, BR
Julio Henrique Rosa Croda - Salvador, BR
Isadora Cristina Siqueira - Salvador, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Los Angeles CA, US
Tracy Ann Young - Berkeley CA, US
Mitermayer Galvão Reis - Salvador, BR
Julio Henrique Rosa Croda - Salvador, BR
Isadora Cristina Siqueira - Salvador, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Los Angeles CA, US
Tracy Ann Young - Berkeley CA, US
Assignee:
The United States of America represented by the Department of Veterans Affairs - Washington DC
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz—Fiocruz - Rio de Janeiro
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz—Fiocruz - Rio de Janeiro
International Classification:
C07H 21/04
US Classification:
536 231, 4353201, 4352523
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Species
US Patent:
8216594, Jul 10, 2012
Filed:
Jan 26, 2012
Appl. No.:
13/359354
Inventors:
Albert I. Ko - Bahia, BR
Mitermayer Galvão Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Florence, IT
Tracy Ann Young - Oakland CA, US
Mitermayer Galvão Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Florence, IT
Tracy Ann Young - Oakland CA, US
Assignee:
The United States of America as represented by the Department of Veterans Affairs - Washington DC
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
International Classification:
A61K 39/002
US Classification:
4242691, 4241911, 530300, 530350
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Species
US Patent:
8124110, Feb 28, 2012
Filed:
Aug 23, 2011
Appl. No.:
13/216214
Inventors:
Albert I. Ko - Bahia, BR
Mitermayer Galvão Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Florence, IT
Tracy Ann Young - Oakland CA, US
Mitermayer Galvão Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Florence, IT
Tracy Ann Young - Oakland CA, US
Assignee:
The United States of America as represented by the Department of Veterans Affairs - Washington DC
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz - FIOCRUZ - Rio de Janeiro
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz - FIOCRUZ - Rio de Janeiro
International Classification:
A61K 39/002
US Classification:
4242691, 4241911, 530300, 530350
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
Proteins With Repetitive Bacterial-Ig-Like (Big) Domains Present In Species
US Patent:
8021673, Sep 20, 2011
Filed:
Apr 1, 2011
Appl. No.:
13/078879
Inventors:
Albert I. Ko - Bahia, BR
Mitermayer Galvào Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Florence, IT
Tracy Ann Young - Oakland CA, US
Mitermayer Galvào Reis - Bahia, BR
Julio Henrique Rosa Croda - Bahia, BR
Isadora Cristina Siqueira - Bahia, BR
David A. Haake - Los Angeles CA, US
James Matsunaga - Los Angeles CA, US
Lee W. Riley - Berkeley CA, US
Michele Barocchi - Florence, IT
Tracy Ann Young - Oakland CA, US
Assignee:
The United States of America as represented by the Department of Veterans Affairs - Washington DC
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz—FIOCRUZ - Rio de Janeiro
The Regents of the University of California - Oakland CA
Cornell Research Foundation, Inc. - Ithaca NY
Fundação Oswaldo Cruz—FIOCRUZ - Rio de Janeiro
International Classification:
A61K 39/002
US Classification:
4242691, 4241911, 530300, 530350
Abstract:
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with species that are capable of producing disease in humans and other mammals, including those of veterinary importance.