DR. LEE ROBERT BRETTMAN, MD
Osteopathic Medicine at Greystone Ln, North Sudbury, MA
License number
Massachusetts 81909
Category
Osteopathic Medicine
Type
Infectious Disease
Address
Address
183 Greystone Ln, North Sudbury, MA 01776
Phone
(978) 440-9050
(978) 440-9250 (Fax)
(978) 440-9250 (Fax)
Professional information
Method Of Treating Lower Urinary Tract Disorders
US Patent:
2004024, Dec 9, 2004
Filed:
Jun 3, 2004
Appl. No.:
10/859922
Inventors:
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Matthew Fraser - Apex NC, US
Steven Landau - Wellesley MA, US
Matthew Fraser - Apex NC, US
Assignee:
DYNOGEN PHARMACEUTICALS, INC. - BOSTON MA
International Classification:
A61K031/195, A61K031/137
US Classification:
514/561000, 514/650000
Abstract:
The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis comprising coadministering to said subject a first amount of an subunit calcium channel ligand and a second amount of a substituted aminomethyl-phenyl-cyclohexane derivative, wherein the first and second amounts together comprise a therapeutically effective amount. The coadministration of a first amount of an subunit calcium channel ligand and a second amount of a substituted aminomethyl-phenyl-cyclohexane derivative can result in an enhanced or synergistic therapeutic effect, wherein the combined effect is greater than the additive effect resulting from separate administration of the first amount of the subunit calcium channel ligand and the second amount of the substituted aminomethyl-phenyl-cyclohexane derivative.
Methods For Treating Lower Urinary Tract Disorders Using Alpha2Delta Subunit Calcium Channel Modulators With Smooth Muscle Modulators
US Patent:
2008008, Apr 10, 2008
Filed:
Dec 7, 2007
Appl. No.:
11/952422
Inventors:
Matthew Fraser - Apex NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Assignee:
Dynogen Pharmaceuticals, Inc. - Boston MA
International Classification:
A61K 31/135, A61K 31/195, A61K 31/44, A61K 31/445, A61P 13/00
US Classification:
514305000, 514327000, 514561000, 514567000, 514648000
Abstract:
A method is provided for using αδ subunit calcium channel modulators or other compounds that interact with the αδ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, αδ subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Methods For Treating Lower Urinary Tract Disorders Using Alpha2Delta Subunit Calcium Channel Modulators With Smooth Muscle Modulators
US Patent:
2004019, Oct 7, 2004
Filed:
Mar 22, 2004
Appl. No.:
10/805977
Inventors:
Matthew Fraser - Apex NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Assignee:
Dynogen Pharmacueticals, Inc. - Boston MA
International Classification:
A61K031/195
US Classification:
514/561000
Abstract:
A method is provided for using subunit calcium channel modulators or other compounds that interact with the calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, 3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Methods For Treating Lower Urinary Tract Disorders Using Alpha2Delta Subunit Calcium Channel Modulators With Smooth Muscle Modulators
US Patent:
2007006, Mar 15, 2007
Filed:
Nov 13, 2006
Appl. No.:
11/598393
Inventors:
Matthew Fraser - Apex NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Assignee:
Dynogen Pharmaceuticals, Inc. - Waltham MA
International Classification:
A61K 31/195, A61K 31/165
US Classification:
514561000, 514618000
Abstract:
A method is provided for using αδ subunit calcium channel modulators or other compounds that interact with the αδ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, αδ subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Methods For Treating Lower Urinary Tract Disorders Using Alpha2Delta Subunit Channel Modulators With Smooth Muscle Modulators
US Patent:
2008027, Nov 6, 2008
Filed:
Apr 11, 2008
Appl. No.:
12/082419
Inventors:
Matthew Oliver Fraser - Apex NC, US
Karl Bruce Thor - Morrisville NC, US
Edward C. Burgard - Chapel Hill NC, US
Lee R. Brettman - Sudbury MA, US
Steven B. Landau - Wellsley MA, US
Daniel J. Ricca - Rougemont NC, US
Karl Bruce Thor - Morrisville NC, US
Edward C. Burgard - Chapel Hill NC, US
Lee R. Brettman - Sudbury MA, US
Steven B. Landau - Wellsley MA, US
Daniel J. Ricca - Rougemont NC, US
Assignee:
Dynogen Pharmacueticals, Inc. - Boston MA
International Classification:
A61K 31/46, A61K 31/195, A61K 31/216, A61K 31/135, A61K 31/445
US Classification:
514305, 514561, 514534, 514648, 514327
Abstract:
A method is provided for using αδ subunit calcium channel modulators or other compounds that interact with the αδ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, αδ subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Dr. Lee R Brettman, Sudbury MA - MD (Doctor of Medicine)
Specialties:
Infectious Disease Medicine
Address:
183 Greystone Ln, Sudbury 01776
(978) 440-9050 (Phone), (978) 440-9250 (Fax)
(978) 440-9050 (Phone), (978) 440-9250 (Fax)
Certifications:
Infectious Disease, 1980, Internal Medicine, 1977
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Baylor University
Graduated: 1973
U Hosps-Case-West Res
Bellevue Hospital Center
Baylor University
Graduated: 1973
U Hosps-Case-West Res
Bellevue Hospital Center
Methods For Treating Functional Bowel Disorders Using Alpha2 Subunit Calcium Channel Modulators With Smooth Muscle Modulators
US Patent:
2006027, Dec 7, 2006
Filed:
Mar 22, 2004
Appl. No.:
10/549998
Inventors:
Matthew Fraser - Apex NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougermont NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougermont NC, US
International Classification:
A61K 31/22, A61K 31/195, A61K 31/165, A61K 31/16
US Classification:
514551000, 514561000, 514621000, 514626000
Abstract:
A method is provided for using αδ subunit calcium channel modulators or other compounds that interact with the αδ calcium channel subunit in combination with one or, more compounds with smooth muscle modulatory effects to treat functional bowel disorders in patients in need of treatment. According to the present invention, αδ subunit calcium channel modulators include GABA analogs including gabapentin and pregabalin, fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Method Of Administering An Antibody
US Patent:
2001004, Nov 29, 2001
Filed:
Dec 27, 2000
Appl. No.:
09/748960
Inventors:
Lee Brettman - Sudbury MA, US
Judith Fox - San Francisco CA, US
David Allison - Burlingame CA, US
Judith Fox - San Francisco CA, US
David Allison - Burlingame CA, US
International Classification:
A61K039/395
US Classification:
424/142100
Abstract:
Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for 47 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.
Methods For Decreasing Detrusor Muscle Overactivity
US Patent:
2005023, Oct 27, 2005
Filed:
May 10, 2005
Appl. No.:
11/126062
Inventors:
Matthew Fraser - Apex NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Karl Thor - Morrisville NC, US
Edward Burgard - Chapel Hill NC, US
Lee Brettman - Sudbury MA, US
Steven Landau - Wellesley MA, US
Daniel Ricca - Rougemont NC, US
Assignee:
Dynogen Pharmaceuticals, Inc. - Boston MA
International Classification:
A61K031/195, A61K031/165
US Classification:
514561000, 514618000, 514617000
Abstract:
A method is provided for using αδ subunit calcium channel modulators or other compounds that interact with the αδ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, αδ subunit calcium channel modulators include GABA analogs, e.g., gabapentin and pregabalin, fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
Method Of Administering An Antibody
US Patent:
2005009, May 5, 2005
Filed:
Dec 15, 2003
Appl. No.:
10/735863
Inventors:
Lee Brettman - Sudbury MA, US
Judith Fox - San Francisco CA, US
David Allison - Burlingame CA, US
Judith Fox - San Francisco CA, US
David Allison - Burlingame CA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
Genentech, Inc. - South San Francisco CA
Genentech, Inc. - South San Francisco CA
International Classification:
A61K039/395
US Classification:
424141100, 424144100
Abstract:
Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.