Inventors:
Jay A. Berzofsky - Bethesda MD, US
Leon T. Van Den Broeke - Zoutelande, NL
Crystal MacKall - Silver Spring MD, US
Lee J. Helman - Bethesda MD, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 38/00
Abstract:
Disclosed are immunogenic peptides, related fusion proteins, nucleic acids encoding the peptides or fusion proteins, conjugates, expression vectors, host cells, and antibodies. Also, disclosed are pharmaceutical compositions, vaccines for use in the treatment or prevention of cancer, e. g. , alveolar rhabodomyosarcoma, methods of stimulating a T cell to kill a tumor cell, methods of stimulating CD4 and CD8 T cells, and methods of treating or preventing cancer are further provided herein.