Inventors:
Huan Xu - Cincinnati OH, US
Lee A. Denson - Wyoming OH, US
Bruce Aronow - Cincinnati OH, US
Assignee:
CHILDRENS HOSPITAL MEDICAL CENTER - Cincinnati OH
International Classification:
C40B 30/04, C40B 40/08
Abstract:
Disclosed are methods for classifying individuals having or suspected of having an inflammatory bowel disease, such as Crohn's Disease or Ulcerative Colitis, as “responders” or “non-responders” to first-line treatment, generally comprising the steps of a) obtaining, a biological sample from the individual, b) isolating mRNA from the biological sample c) determining a gene expression profile from the biological sample; and d) comparing the gene expression profile of the individual to a reference gene expression profile or other suitable control such that changes in expression can be used to stratify individuals and predict efficacy of first-line therapy. A gene expression system is further provided for carrying out these methods.