LEE A DENSON, M.D.
Medical Practice in Cincinnati, OH

2014001, Jan 16, 2014

Apr 5, 2013

13/857351

Lee A. Denson - Wyoming OH, US
Bruce Aronow - Cincinnati OH, US

Children's Hospital Medical Center - Cincinnati OH

C12Q 1/68

506 9, 435 612, 506 16

Disclosed are methods for classifying individuals having or suspected of having an inflammatory bowel disease, such as Crohn's Disease or Ulcerative Colitis, as ‘responders’ or ‘non-responders’ to first-line treatment, generally comprising the steps of a) obtaining a biological sample from the individual, b) isolating mRNA from the biological sample c) determining a gene expression profile from the biological sample; and d) comparing the gene expression profile of the individual to a reference gene expression profile or other suitable control such that changes in expression can be used to stratify individuals and predict efficacy of first-line therapy. A gene expression system is further provided for carrying out these methods.

2010026, Oct 21, 2010

Oct 17, 2007

12/445764

Huan Xu - Cincinnati OH, US
Lee A. Denson - Wyoming OH, US
Bruce Aronow - Cincinnati OH, US

CHILDRENS HOSPITAL MEDICAL CENTER - Cincinnati OH

C40B 30/04, C40B 40/08

506 9, 506 17

Disclosed are methods for classifying individuals having or suspected of having an inflammatory bowel disease, such as Crohn's Disease or Ulcerative Colitis, as “responders” or “non-responders” to first-line treatment, generally comprising the steps of a) obtaining, a biological sample from the individual, b) isolating mRNA from the biological sample c) determining a gene expression profile from the biological sample; and d) comparing the gene expression profile of the individual to a reference gene expression profile or other suitable control such that changes in expression can be used to stratify individuals and predict efficacy of first-line therapy. A gene expression system is further provided for carrying out these methods.

2010025, Oct 7, 2010

Mar 28, 2008

12/058230

Lee A. Denson - Wyoming OH, US
Bruce Colston Trapnell - Hamilton OH, US
Kanji Uchida - Tokyo, JP

G01N 33/53

435 792, 435 71

Disclosed are novel biomarkers and methods related to diagnostic tests for the detection and characterization of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. In particular, the instant invention relates to novel biomarkers and methods of using such biomarkers to predict disease behavior and severity, to differentiate among disease types, and to optimize selection of treatment options in individuals suspected of having an inflammatory bowel disease.

2013027, Oct 17, 2013

May 24, 2011

13/114078

Lee Denson - Wyoming OH, US
Bruce Colston Trapnell - Hamilton OH, US
Kanji Uchida - Tokyo, JP

G01N 33/68

435 721, 436501, 435 792, 435 71

Disclosed are novel biomarkers and methods related to diagnostic tests for the detection and characterization of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. In particular, the instant invention relates to novel biomarkers and methods of using such biomarkers to predict disease behavior and severity, to differentiate among disease types, and to optimize selection of treatment options in individuals suspected of having an inflammatory bowel disease.