Inventors:
Pu Liu - Bethesda MD, US
Wei Zheng - Potomac MD, US
Juan Marugan - Gaithersburg MD, US
Noel T. Southall - Chevy Chase MD, US
Lea Cunningham - Washington DC, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Services - Bethesda MD
International Classification:
A61K 31/5513, A61K 45/06, A61K 31/40
US Classification:
424 852, 514221, 514423, 514 49, 514 34, 514400, 4241781, 514 46
Abstract:
A method for treating core binding factor (CBF) leukemia in a subject, comprising administering to a subject having CBF leukemia a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, that inhibits CBFβ and RUNX1 binding in the subject, thereby treating the CBF leukemia.