LAWRENCE XAVIER WEBB, MD
Medical Practice at Medical Center Blvd, Winston Salem, NC

2008018, Jul 31, 2008

Jan 30, 2007

11/699688

Lawrence X. Webb - Winston-Salem NC, US

A61K 31/05, A61K 36/899, A61K 38/43, A61K 38/46

424489, 424750, 424 941, 424 946, 514733

A dietary supplement includes resveratrol in a therapeutically effective amount to permit release of nitric oxide (NO) during sexual stimulation and at least one polyphenol in a therapeutically effective amount to inhibit formation of type 5 phosphodiesterase (PDE-5). The dietary supplement is a dry powder derived from Muscadine grapes that are pressed and then stored at a temperature greater than 32° F. (0° C.) and less than 60° F. (15° C.) for at least 14 days. The pressed and stored grapes are dried and then ground into the dry powder. The concentration of the resveratrol is between 0.01 mg and 100 mg per 100 g of dry powder and the concentration of the polyphenol is between 0.04 mg and 400 mg per 100 g. A method for enhancing human libido includes providing the dry powder and consuming at least 50 mg of the dry powder daily for a period of at least 21 days.

7853311, Dec 14, 2010

Apr 21, 2000

09/553683

Lawrence Xavier Webb - Winston-Salem NC, US

3M Innovative Properties Company - St. Paul MN

A61B 5/00

600426, 128849

A targeting device for providing a series of coordinates/lines within a sheet of sterile, flexible material with an adherent surface which is applied to the skin (after suitable surgical preparation). The sheet is non-porous and may have a topical antiseptic on the side which is applied to the skin. A fluoroscope or roentgenographic image of the portion of the body to which the adherent film is applied will show the underlying skeletal and radiopaque elements as well as the overlying surgical grid. Once the targeting device is applied, the coordinates on the grid lines are clearly visible on the surface of the skin as well as on the fluoroscopic or radiographic image and by knowing the direction of the fluoroscopic or radiographic beam, the operator will be able to thereby correlate a specific locus on the skin with an underlying skeletal element or other underlying radiopaque structure. By applying the targeting device to the part of the body in a circumferential or nearly circumferential manner, and utilizing a radiolucent operating room table, and a radiograph or C-arm fluoroscope, targeting techniques using the targeting device can be utilized at surgery. Multiple targeting or percutaneous procedures can be performed at the same sitting with the application of a single device.

2013003, Jan 31, 2013

Oct 2, 2012

13/633627

Wake Forest University Health Sciences - Winston-Salem NC, US
Michael J. Morykwas - Winston-Salem NC, US
Lawrence X. Webb - Winston-Salem NC, US

WAKE FOREST UNIVERSITY HEALTH SCIENCES - Winston-Salem NC

A61M 1/00

604319

A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.

7931651, Apr 26, 2011

Mar 30, 2007

11/694395

Lawrence X. Webb - Winston-Salem NC, US
Louis C. Argenta - Winston-Salem NC, US
Michael J. Morykwas - Winston-Salem NC, US

Wake Lake University Health Sciences - Winston-Salem NC

A61F 5/04

606 59, 606 54, 606304, 606323

An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.

8377016, Feb 19, 2013

Jan 10, 2007

11/621728

Louis O. Argenta - Winston-Salem NC, US
Michael J. Morykwas - Winston-Salem NC, US
Lawrence X. Webb - Winston-Salem NC, US

Wake Forest University Health Sciences - Winston-Salem NC

A61F 13/00

604305, 604289, 604290, 604306, 604307, 604308, 604313, 604315, 604316, 600573, 600575, 424447, 424448, 424449

A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.

8454603, Jun 4, 2013

Apr 26, 2011

13/094233

Lawrence X. Webb - Winston-Salem NC, US
Louis C. Argenta - Winston-Salem NC, US
Michael J. Morykwas - Winston-Salem NC, US

Wake Forest University Health Sciences - Winston-Salem NC

A61F 5/04

606 59, 604543, 606304

An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.

2004012, Jun 24, 2004

Aug 22, 2003

10/647068

Louis Argenta - Winston-Salem NC, US
Michael Morykwas - Winston-Salem NC, US
Lawrence Webb - Winston-Salem NC, US

A61F005/00

606/086000

A method of treating bone tissue damage is provided which includes applying a reduced pressure to a damaged bone tissue sufficient in time and magnitude to promote healing of the damaged bone tissue. A bone tissue treatment apparatus is provided in which a cover is sealed over a bone tissue site. A screen in the form of an open-cell foam screen or a rigid porous screen may be placed beneath the tissue cover over the damaged bone tissue. A vacuum pump supplies suction within the tissue cover over the treatment site. The cover may be sealed over an area of intact skin above damaged bone tissue. The vacuum pump supplies reduced pressure within the tissue cover over the area of intact skin to treat the damaged bone tissue beneath the area of skin.

2008020, Aug 28, 2008

Feb 23, 2007

11/678403

Louis C. Argenta - Winston-Salem NC, US
Michael J. Morykwas - Winston-Salem NC, US
Lawrence X. Webb - Winston-Salem NC, US

A61M 1/00

604540

The present invention relates to a device and method for removing edema from an edematous tissue. The device includes at least one aciculated component disposed in fluid communication with a suction manifold. A suction source is fluidically connected to the suction manifold to provide a suction force to the suction manifold. The suction force is transmitted through the suction manifold to the at least one aciculated component to withdraw the edema from edematous tissue through the suction manifold and the at least one aciculated component.

2010018, Jul 22, 2010

Sep 28, 2007

12/443249

David L. Carroll - Winston-Salem NC, US
Faith M. Coldren - Strasbourg, FR
Nicole H. Levi - Winston-Salem NC, US
Lawrence X. Webb - Winston-Salem NC, US
William D. Wagner - Clemmons NC, US
Thomas L. Smith - Winston-Salem NC, US
Brian Werner - Lancaster PA, US
J. Baxter Mcguirt - Winston-Salem NC, US
Manoj Namboothiry - West Lafayette IN, US

WAKE FOREST UNIVERSITY HEALTH SCIENCES - Winston-Salem NC
WAKE FOREST UNIVERSITY - Winston-Salem NC

A61B 5/103

600587

The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.

2003022, Dec 4, 2003

Jun 3, 2002

10/161076

Louis Argenta - Winston-Salem NC, US
Michael Morykwas - Pfafftown NC, US
Lawrence Webb - Winston-Salem NC, US

A61H007/00

601/006000

A tissue growth apparatus and method are provided for growing tissue by applying a tissue growth medium to the tissue and applying reduced, sub-atmospheric pressure at the growth medium and the tissue in a controlled manner for a selected time period. The application of reduced pressure at the growth medium and tissue promotes growth of the tissue within the tissue growth medium. The apparatus includes a tissue cover sealed over a tissue site. The apparatus also includes a tissue growth medium located beneath the tissue cover and in contact with the tissue to be grown. A vacuum pump supplies suction within the tissue cover over the tissue site to provide reduced pressure to the tissue and the tissue growth medium.