MR. LAWRENCE L MARTIN, R.PH.
Pharmacy at Reading Rd, Flemington, NJ

5840749, Nov 24, 1998

Mar 8, 1994

8/207464

Richard C. Allen - Flemington NJ
Grover C. Helsley - Stockton NJ
R. Richard L. Hamer - Lebanon NJ
Brian S. Freed - Somerset NJ
John I. White - Chapel Hill NC
Lawrence L. Martin - Lebanon NJ

Hoechst Marion Roussel, Inc. - Cincinnati OH

A61K 31335, C07D31312

514450

This invention relates to N-hydroxy-dibenz�b,e!oxepinalkylamines, N-hydroxy-dibenz�b,e!oxepinalkanoic acid amides and related heterocyclic analogues of the formula ##STR1## where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; R. sup. 1 is hydrogen, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; R. sup. 2 is loweralkyl, cycloalkyl, arylloweralkyl, loweralkoxycarbonyl, loweralkylcarbonyl, arylcarbonyl or arylloweralkylcarbonyl; m is 0 or 1 and n is an integer of 0 to 4 or the pharmaceutically acceptable salts thereof. The compounds of this invention are useful as analgesics and topical antiinflammatory agents for the treatment of various dermatoses and agents for the treatment of conditions where accumulation of cyclooxygenase and/or lipoxygenase metabolites is a causative factor.

4482547, Nov 13, 1984

Aug 26, 1982

6/412047

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst-Roussel Pharmaceuticals Inc. - Sommerville NJ

A61K 3155, C07D25504

424244

This invention relates to substituted-1,3,4-benzotriazepines of the formula ##STR1## wherein X and Y are each independently hydrogen, lower alkyl, halogen, lower alkoxy, nitro and hydroxyl; R. sub. 1 and R. sub. 3 are each independently hydrogen or alkyl; R. sub. 2 is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, Ar lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tautomeric form when the substituent for R. sub. 1 and/or R. sub. 3 in the above formula is hydrogen. The compound of this invention may be used as antihypertensive agents.

5856335, Jan 5, 1999

Jan 8, 1997

8/780525

Richard Charles Effland - Bridgewater NJ
Joseph Thomas Klein - Bridgewater NJ
Lawrence Leo Martin - Lebanon NJ

Hoechst Marion Roussel, Inc. - Cincinnati OH

C07D47104, C07D48704, A61K 3144

514301

This application relates to compounds of the formula ##STR1## wherein R. sup. 1, R. sup. 2, R. sup. 3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.

5229517, Jul 20, 1993

Jan 15, 1992

7/821364

Lawrence L. Martin - Lebanon NJ
Denise M. Flanagan - Livingston NJ
Joseph F. Payack - Somerset NJ

Hoechst-Roussel Pharmaceuticals Incorporated - Somerville NJ

C07D40100, C07D20942

546201

Novel 2-(4-piperidinyl)-1H-pyrido[4,3-b]indol-1-ones and related compounds, intermediates and processes for the preparation thereof, and methods of treating psychoses employing compounds and compositions thereof are disclosed.

5646300, Jul 8, 1997

Jun 1, 1995

8/457649

Raymond W. Kosley - Bridgewater NJ
Denise M. Flanagan - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ
Peter A. Nemoto - Piscataway NJ

Hoechst Marion Roussel, Inc. - Cincinnati OH

C07D20910, C07D49304

548475

There are disclosed neuroprotective compounds having the formula ##STR1## wherein the moieties are defined in the specification, and processes for making them.

4526891, Jul 2, 1985

Mar 10, 1983

6/474106

Lawrence L. Martin - Lebanon NJ
Linda L. Setescak - Somerville NJ

Hoechst Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 31495, C07D40506

514253

This invention relates to compounds of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF. sub. 3 ; R is H, and lower alkyl, R. sub. 1 is CH. sub. 3 SO. sub. 3 and ##STR2## where R. sub. 2 and R. sub. 3 are the same or different and are hydrogen, lower alkyl, mesyl (CH. sub. 3 SO. sub. 2 --), and cycloalkyl loweralkyl; ##STR3##.

5428053, Jun 27, 1995

Sep 28, 1993

8/102181

Lawrence L. Martin - Lebanon NJ
Raymond W. Kosley - Bridgewater NJ
Denise M. Flanagan - Bridgewater NJ
Gert U. Kuerzel - Hofheim, DE
Peter A. Nemoto - Raritan NJ
David G. Wettlaufer - Phillipsburg NJ

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

A61K 3140, C07D20750, C07D40306

514422

There are disclosed 1-aminoacetamidopyrroles and 1-amino-2-(substituted) pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias.

4459231, Jul 10, 1984

Sep 8, 1981

6/300021

Lawrence L. Martin - Lebanon NJ
Manfred Worm - Wiesbaden-Naurod, DE
Charles A. Crichlow - Piscataway NJ

Hoechst-Roussel Pharmaceuticals, Incorporated - Somerville NJ

C07D24304

260239BD

Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.

4288623, Sep 8, 1981

Nov 28, 1980

6/211148

Lawrence L. Martin - Lebanon NJ
Manfred Worm - Wiesbaden-Naurod, DE

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

C07C 87452

564307

Sprio[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.

4459230, Jul 10, 1984

Sep 8, 1981

6/299841

Lawrence L. Martin - Lebanon NJ
Manfred Worm - Wiesbaden-Naurod, DE
Charles A. Crichlow - Piscataway NJ

Hoechst-Roussel Pharmaceuticals, Incorporated - Somerville NJ

C07D24304

260239BD

Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.