LAWRENCE HOWARD BLOCK
Pharmacy in Pittsburgh, PA
License number
Pennsylvania RP027781L
Category
Pharmacy
Type
Pharmacist
Address
Address
Pittsburgh, PA 15220
Personal information
See more information about LAWRENCE HOWARD BLOCK at radaris.comName
Address
Phone
3006 Edinburg Ct, Carnegie, PA 15106
208 Old Haymaker Rd, Monroeville, PA 15146
605 Tally Dr, Pittsburgh, PA 15237
605 Tally Dr, Pittsburgh, PA 15237
4848 Swallow Hill Rd, Carnegie, PA 15106
Professional information
Methods Of Creating A Unique Chitosan And Employing The Same To Form Complexes With Drugs, Delivery Of The Same Within A Patient And A Related Dosage Form
US Patent:
5830883, Nov 3, 1998
Filed:
Nov 6, 1995
Appl. No.:
8/544428
Inventors:
Lawrence H. Block - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Assignee:
Duquesne University of the Holy Ghost - Pittsburgh PA
International Classification:
A61K 3173, A61K 922, A61F 1300
US Classification:
514 55
Abstract:
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3. 5 kDa to 250 kDa and preferably about 3. 5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization.
Methods Of Creating A Unique Chitosan And Employing The Same To Form Complexes With Drugs, Delivery Of The Same Within A Patient And A Related Dosage Form
US Patent:
5900408, May 4, 1999
Filed:
Feb 18, 1997
Appl. No.:
8/802311
Inventors:
Lawrence H. Block - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Assignee:
Duquesne University of the Holy Ghost - Pittsburgh PA
International Classification:
A61K 3173, A61K 922, A61F 1300
US Classification:
514 55
Abstract:
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3. 5 kDa to 250 kDa and preferably about 3. 5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization.
Lawrence Block
Specialties:
Pharmacy
Work:
Duquesne University