LAWRENCE HOWARD BLOCK
Pharmacy in Pittsburgh, PA
License number
Pennsylvania RP027781L
Category
Pharmacy
Type
Pharmacist
Address
Address
Pittsburgh, PA 15220
Professional information
Methods Of Creating A Unique Chitosan And Employing The Same To Form Complexes With Drugs, Delivery Of The Same Within A Patient And A Related Dosage Form
US Patent:
5830883, Nov 3, 1998
Filed:
Nov 6, 1995
Appl. No.:
8/544428
Inventors:
Lawrence H. Block - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Assignee:
Duquesne University of the Holy Ghost - Pittsburgh PA
International Classification:
A61K 3173, A61K 922, A61F 1300
US Classification:
514 55
Abstract:
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3. 5 kDa to 250 kDa and preferably about 3. 5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization.
Methods Of Creating A Unique Chitosan And Employing The Same To Form Complexes With Drugs, Delivery Of The Same Within A Patient And A Related Dosage Form
US Patent:
5900408, May 4, 1999
Filed:
Feb 18, 1997
Appl. No.:
8/802311
Inventors:
Lawrence H. Block - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Shobhan S. Sabnis - Pittsburgh PA
Assignee:
Duquesne University of the Holy Ghost - Pittsburgh PA
International Classification:
A61K 3173, A61K 922, A61F 1300
US Classification:
514 55
Abstract:
A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3. 5 kDa to 250 kDa and preferably about 3. 5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization.
Lawrence Block
Specialties:
Pharmacy
Work:
Duquesne University