Inventors:
Lawrence Chan - Houston TX, US
Hideto Kojima - Houston TX, US
Tomoya Terashima - Houston TX, US
Assignee:
BAYLOR COLLEGE OF MEDICINE - Houston TX
International Classification:
A61K 9/127, C07K 7/06, A61K 38/08, C07K 19/00, A61K 35/76, A61K 38/20, C07H 21/00, A61P 25/00, A61P 35/00, A61P 31/00, A61P 3/00
US Classification:
424450, 530329, 514 217, 424 936, 424 852, 514 177, 536 234
Abstract:
The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.