Inventors:
James L. Michel - Waban MA
Dennis L. Kasper - Newton MA
Frederick M. Ausubel - Newton MA
Lawrence C. Madoff - Boston MA
Assignee:
The General Hospital Corporation - Boston MA
Brigham and Women's Hospital - Boston MA
International Classification:
A61K 3940, A61K 39385, A61K 3909, C07K 104
Abstract:
A vaccine capable of protecting a recipient from infection caused by group B Streptococcus. The vaccine provides polysaccharide-protein moieties and contain (a) a group B Streptococcus polysaccharide conjugated to (b) a functional derivative of a group B Streptococcus C protein alpha antigen that retains the ability to elicit protective antibodies against group B Streptococcus. The vaccine may contain only one type of such polysaccharide-protein unit or may contain a mixture of more than one type of unit.