Inventors:
Lawrence A. Solberg - Jacksonville FL, US
Frederic J. de Sauvage - South San Francisco CA, US
Daniel L. Eaton - South San Fransisco CA, US
International Classification:
C07K 14/435
Abstract:
A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified. This protein, the porcine Mpl ligand polypeptide (ML), binds to and activates the c-Mpl receptor protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand stimulates both megakaryocytopoiesis and thrombopoiesis.