Inventors:
Laurie H. Glimcher - New York NY, US
Dallas C. Jones - Brookline MA, US
Marc Wein - Brookline MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
G01N 33/50, A61K 38/17, A61K 31/713, A61K 31/7088
US Classification:
424 92, 514 44 A, 514 167, 514 169, 514 168, 514 166, 506 10, 435375
Abstract:
This invention is based, at least in part, on the discovery that Shn2 and Shn3 play an important role in skeletal remodeling and skeletal patterning. Accordingly, the present invention provides methods for identifying medulators of Shn2 activity and methods for modulating bone formation and mineralization and Shn2-associated disorders using agents that modulate Shn2 expression and/or activity, in addition to methods for modulating Shn2 and Shn3.