DR. LAURENCE H. TECOTT, M.D.
Psychiatric at Parnassus Ave, San Francisco, CA

5698766, Dec 16, 1997

Apr 5, 1995

8/417592

David J. Julius - San Francisco CA
Laurence H. Tecott - San Francisco CA
Linda M. Sun - San Francisco CA

The Regents of the University of California - Oakland CA

C07H 2104, C12N 506, C12N 1506, C12Q 168

800 2

A transgenic, non-human animal model is disclosed which lacks receptors which mediate some of the central nervous system (CNS) actions of serotonin. The animal is preferably from a genus selected from the group consisting of Mus (e. g. , mice), Rattus (e. g. , rats), Oryctologus (e. g. , rabbits) and Mesocricetus (e. g. , hamsters). More preferably the animal is a mouse which lacks 5HT. sub. 2c receptors. Animals lacking such receptors are overweight due to abnormal control of feeding behavior and are prone to spontaneous death from seizures. Thus, such animals provide an animal model for the testing of drugs which are potentially useful in the treatment of eating disorders and diseases such as epilepsy which result in seizures.

2010032, Dec 23, 2010

Jan 21, 2009

12/863970

Evan Goulding - San Francisco CA, US
A. Katrin Schenk - San Francisco CA, US
Laurence Tecott - San Francisco CA, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

G06F 19/00

702150

Systems and methods for the analysis of the diverse behaviors of animal subjects in defined areas are provided, including tools for filtering and analysis of high-resolution behavioral data. These systems and methods provide an opportunity to examine behavioral patterns with levels of precision and quantization that have not been previously achieved. Methods and systems for managing and analyzing the very large and unique datasets produced by behavioral monitoring systems, including quality assessment and control, archiving, data query, data reduction, analytical procedures and visualization techniques are provided. Such detailed analyses of spontaneous behavior provide fundamental insights into the neural organization of behavior and enable detection of genetic, pharmacological and environmental influences on brain function with high sensitivity.

7086350, Aug 8, 2006

Jul 25, 2003

10/627187

Laurence H. Tecott - San Francisco CA, US
Evan Goulding - San Francisco CA, US

The Regents of the University of California - Oakland CA

A01K 1/03

119421

A behavioral monitoring system useful for the analysis of complex behaviors in a number of animal species. The monitoring systems of this invention allow continuous monitoring of feeding, drinking and movement of animals with high temporal and spatial resolution. In certain embodiments, the system comprises an enclosure comprising: an animal position indicator; a food consumption indicator; and a fluid consumption indicator, where the system reports behavioral data at a temporal resolution of 20 seconds or lower.

6060642, May 9, 2000

Aug 11, 1998

9/132388

Laurence H. Tecott - San Francisco CA
Thomas J. Brennan - San Carlos CA

The Regents of the University of California - Oakland CA

C12N 500, C12N 1512, A01K 67027, G01N 3315, C07H 2104

800 3

The present invention features transgenic mice models for gene function, wherein the transgenic mice are characterized by having altered serotonin 5-HT6 receptor gene function. The transgenic mice may be either homozygous or heterozygous for a disruption in the endogenous 5-HT6 gene. Transgenic mice homozygous for a disruption in the endogenous 5-HT6 gene display a phenotype of increased anxiety behavior including diminished investigation of foreign objects and an elevation in stretched attend postures.