LAURENCE C EISENLOHR
Veterinary in Merion Station, PA
License number
Pennsylvania BV005352L
Category
Veterinary Medicine
Type
Veterinarian
Address
Address
Merion Station, PA 19066
Professional information
Method Of Inducing An Immune Response Using Vaccinia Virus Recombinants
US Patent:
6475999, Nov 5, 2002
Filed:
Jun 19, 2000
Appl. No.:
09/596716
Inventors:
Michael J. Mastrangelo - Jenkintown PA
Edmund C. Lattime - Princeton NJ
David Berd - Wyncote PA
Laurence C. Eisenlohr - Merion PA
Edmund C. Lattime - Princeton NJ
David Berd - Wyncote PA
Laurence C. Eisenlohr - Merion PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 4800
US Classification:
514 44, 4353201, 435455, 435325
Abstract:
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
Method Of Inducing An Immune Response Using Vaccinia Virus Recombinants Encoding Gm-Csf
US Patent:
6093700, Jul 25, 2000
Filed:
Feb 20, 1997
Appl. No.:
8/732505
Inventors:
Michael J. Mastrangelo - Jenkintown PA
Edmund C. Lattime - Princeton NJ
David Berd - Wyncote PA
Laurence C. Eisenlohr - Merion PA
Edmund C. Lattime - Princeton NJ
David Berd - Wyncote PA
Laurence C. Eisenlohr - Merion PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 4800, C12N 1500
US Classification:
514 44
Abstract:
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
Method For Assessing Recording In Vitro And In Vivo
US Patent:
2004021, Oct 28, 2004
Filed:
Jul 28, 2003
Appl. No.:
10/627588
Inventors:
Laurence Eisenlohr - Merion Station PA, US
Michael Howard - Salt Lake City UT, US
Michael Howard - Salt Lake City UT, US
International Classification:
C12Q001/68, C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Recoding of the genetic code, through +1 frameshifting, -1 frameshifting or stop codon readthrough, will alter the protein that is translated from that gene. Current systems that quantify recoding events have limited sensitivity, and can only be used in cell extracts or tissue culture. A novel method for detecting a recoding event is described that uses the sensitivity and specificity of CD8+ T-cells for measuring recoding, both in vivo and in vitro. This enhanced sensitivity allows for the identification of compounds that are used to regulate recoding, and therefore protein translation.
Method Of Inducing An Immune Response Using Vaccinia Virus Recombinants
US Patent:
2003008, May 8, 2003
Filed:
Nov 4, 2002
Appl. No.:
10/288663
Inventors:
Michael Mastrangelo - Jenkintown PA, US
Edmund Lattime - Princeton NJ, US
David Berd - Wyncote PA, US
Laurence Eisenlohr - Merion PA, US
Edmund Lattime - Princeton NJ, US
David Berd - Wyncote PA, US
Laurence Eisenlohr - Merion PA, US
International Classification:
A61K048/00, C12N007/00, C12N015/869
US Classification:
424/093200, 514/044000, 435/456000, 435/235100
Abstract:
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
Novel Method For Assessing Recoding In Vitro And In Vivo
US Patent:
2002006, Jun 6, 2002
Filed:
Oct 16, 2001
Appl. No.:
09/981393
Inventors:
Laurence Eisenlohr - Merion Station PA, US
Michael Howard - Salt Lake City UT, US
Michael Howard - Salt Lake City UT, US
International Classification:
C12Q001/70, C12Q001/68
US Classification:
435/005000, 435/006000, 435/455000
Abstract:
Recoding of the genetic code, through +1 frameshifting, -1 frameshifting or stop codon readthrough, will alter the protein that is translated from that gene. Current systems that quantify recoding events have limited sensitivity, and can only be used in cell extracts or tissue culture. A novel method for detecting a recoding event is described that uses the sensitivity and specificity of CD8+ T-cells for measuring recoding, both in vivo and in vitro. This enhanced sensitivity allows for the identification of compounds that are used to regulate recoding, and therefore protein translation.