Inventors:
David Ward - New Haven CT, US
Peter Lichter - Heidelberg, DE
Thomas Cremer - Heidelberg, DE
Laura Manuelidis - New Haven CT, US
Thomas Ried - Heidelberg, DE
Antonio Baldini - London, GB
Assignee:
YALE UNIVERSITY - New Haven CT
International Classification:
C12Q001/68, C12N015/85
Abstract:
This disclosure relates to a method of specifically decorating selected mammalian chromosomes and of detecting, identifying and and/or quantitating selected individual chromosomes, by means of chromosomal in situ suppression (CISS) hybridization. The method is useful in analyzing cells for the occurrence of chromosomes, chromosome fragments or chromosome aberrations.