Inventors:
K. Sreekumaran Nair - Rochester MN, US
Laura J. Greenlund - Rochester MN, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
A01K 67/027, A01K 67/00, A01K 67/033, G01N 33/00, C12N 15/00, C12N 5/00, C12P 21/06
US Classification:
800 18, 800 3, 800 8, 800 9, 800 14, 800 21, 800 24, 800 25, 435 691, 4353201, 435325, 435455
Abstract:
Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating type 2 diabetes, and methods for altering the ratio of MHCI to MHCII in a subject.