Inventors:
Laszlo Csatary - Alexandria VA, US
Joseph Szeberenyi - Sziget, HU
Zsolt Fabian - Sziget, HU
Assignee:
United Cancer Research Institute - Alexandria VA
International Classification:
A61K 35/76, A61K 38/16, A61K 31/525, A61K 33/24
US Classification:
424093600, 424649000, 514251000, 514283000, 514008000
Abstract:
A method for treating human tumor cells to induce apoptotic cell death thereof includes the step of infecting the tumor cells with a combination of the Herefordshire strain of Newcastle Disease Virus and a chemotherapeutic agent. The range of concentrations of chemotherapeutic agent/Herefordshire strain is in the range of 100/1 to 1/1. Illustrative chemotherapeutic agents include cisplatin, methotrexate, vincristine, bleomycin and dacarbazine.