Inventors:
Susanne M. Brown - Glasgow, GB
Alasdair R. Maclean - Glasgow, GB
Nigel W. Fraser - Philadelphia PA, US
Bruce P. Randazzo - Philadelphia PA, US
Steven Albelda - Philadelphia PA, US
Larry Kaiser - Philadelphia PA, US
John Kucharczuk - Philadelphia PA, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
CRUSADE LABORATORIES LIMITED - Aldwych
WISTAR INSTITUTE - Philadelphia PA
International Classification:
A61K 35/76, A61P 35/00, A61P 35/04
Abstract:
A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.