Inventors:
Larry Thomas - Chicago IL, US
Assignee:
Rush University Medical Center
International Classification:
A61K038/40, C12Q001/00
Abstract:
This invention relates to assays for determining whether lactoferrin-mediated leukocyte activation occurs and measuring the strength of any reaction. Generally, lactoferrin, in soluble or immobilized form, is contacted with a cell population containing leukocytes and the level of leukocyte activation is determined typically through superoxide production. The assays can also be carried out in the presence of one or more potential regulators of lactoferrin-mediated leukocyte activation to determine any effect on activation.