LARRY ALLEN, MD
Osteopathic Medicine at 16 Ave, Denver, CO

6482436, Nov 19, 2002

Jan 6, 1999

09/226818

Viktor A. Volkonsky - Mosow, RU
Sergei D. Dyuksherstnov - Mosow, RU
Sergi V. Chernyakov - Mosow, RU
Larry M. Allen - Golden CO
Thomas B. Kent - Boulder CO

FeRx Incorporated - San Diego CA

A61K 914

424489, 424490, 424443, 424448, 424445, 424447

A magnetically controllable, or guided, ferrocarbon particle composition and methods of use and production are disclosed. The composition may optionally carry biologically active substances that have been adsorbed onto the particle. The composition comprises composite, volume-compounded particles of 0. 1 to 5. 0 m in size, and preferably between 0. 5 and 5. 0 m, containing 1. 0 to 95. 0% by mass of carbon, and preferably from about 20% to about 60%. The particles may be produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are optionally placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension.

6200547, Mar 13, 2001

Jan 6, 1998

9/003286

Viktor A. Volkonsky - Moscow, RU
Sergei D. Dyuksherstnov - Moscow, RU
Sergi V. Chernyakov - Moscow, RU
Larry M. Allen - Golden CO
Thomas B. Kent - Boulder CO

FeRx Incorporated - San Diego CA

A61K 916, A61K 950, A61B 5055

424 936

A magnetically controllable, or guided, carrier composition and methods of use and production are disclosed, the composition for carrying biologically active substances to a treatment zone in a body under control of a magnetic field. The composition comprises composite, volume-compounded paclitaxel-adsorbed particles of 0. 2 to 5. 0. mu. m in size, and preferably between 0. 5 and 5. 0. mu. m, containing 1. 0 to 95. 0% by mass of carbon, and preferably from about 20% to about 60%. The particles are produced by mechanical milling of a mixture of iron and carbon powders. The obtained particles are placed in a solution of a biologically active substance to adsorb the substance onto the particles. The composition is generally administered in suspension. Magnetic carrier particles having therapeutic quantities of adsorbed paclitaxel, doxorubicin, Tc. sup.

5008294, Apr 16, 1991

Jun 3, 1987

7/057481

Edward S. Neiss - Denver CO
Larry M. Allen - Golden CO

Chemex Pharmaceuticals, Inc. - Denver CO

A61K 3105

514731

The invention relates to methods useful in the treatment of benign, premalignant and malignant solid tumors, especially those of the skin comprising methods for the administration of pharmacologically active compositions containing catecholic butanes. The invention also relates to methods of preventing the occurence of tumors, and the use of catecholic butanes as a sunscreening agent. The preferred catecholic butane is nordihydroguaiaretic acid. The preferred methods of application of the compositions containing catecholic butanes are by topical application and intratumor injection.

4895727, Jan 23, 1990

May 3, 1985

6/730682

Larry M. Allen - Denver CO

Chemex Pharmaceuticals, Inc. - Denver CO

A61K 3332, A61K 31315, A61K 3156, A61K 3105

424642

This invention is a method of inducing a reservoir effect in skin and mucous membranes so as to enhance penetration and retention and reduce transdermal flux of topically applied therapeutic and cosmetic pharmacologically active agents. The invention also relates to topical treatment methods involving such reservior effect enhancers, and to pharmaceutical compositions containing them.

5276060, Jan 4, 1994

Apr 15, 1991

7/685609

Edward S. Neiss - Denver CO
Larry M. Allen - Golden CO
Russell T. Jordan - Fort Collins CO

Block/Chemex, G.P. - Jersey City NJ

A61K 3105

514731

The invention relates to methods useful in the treatment of benign, premalignant and malignant solid tumors, especially those of the skin comprising methods for the administration of pharmacologically active compositions containing catecholic butanes. The invention also relates to methods of preventing the occurrence of tumors, and the use of catecholic butanes as a sunscreening agent. The preferred catecholic butane is nordihydroguaiaretic acid. The preferred methods of application of the compositions containing catecholic butanes are by topical application and intratumor injection.